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Symptomatic Knee Osteoarthritis clinical trials

View clinical trials related to Symptomatic Knee Osteoarthritis.

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NCT ID: NCT04886258 Recruiting - Clinical trials for Symptomatic Knee Osteoarthritis

Study of Efficacy, Safety and Tolerability of DFV890 in Patients With Knee Osteoarthritis

Start date: September 20, 2021
Phase: Phase 2
Study type: Interventional

This is a double-blinded, two-arm, phase II study to assess efficacy, safety and tolerability of DFV890 in participants with symptomatic knee osteoarthritis. The study includes a screening period, a treatment period and a follow-up period. At most, the study duration is 21 weeks.

NCT ID: NCT04783792 Completed - Clinical trials for Symptomatic Knee Osteoarthritis

The Effect of Phenolic Compounds in Osteoarthritis; a Nutritional Intervention

Start date: November 1, 2020
Phase: N/A
Study type: Interventional

The main objective of the study is to elucidate the beneficial effect of a dietary supplement with phenolic compounds in patients with OA versus ascorbic acid. The analysis of the data is expected to clarify the role of the new supplement as one with a positive effect on OA-related biomarkers, on functional abilities and on the quality of life of patients with OA.

NCT ID: NCT03527693 Completed - Clinical trials for Symptomatic Knee Osteoarthritis

Micro-fragmented Adipose Tissue Injection Associated With Arthroscopic Procedures in Patients With Knee Osteoarthritis

LOOK
Start date: January 1, 2015
Phase:
Study type: Observational

The study aims to evaluate the effects of a single intra-articular injection of micro-fragmented adipose tissue obtained with the Lipogems® system in patients affected by knee chondropathy. End-points were determined by evaluating the patients in terms of improvement in symptoms, functional recovery and radiographic appearance compared to baseline.

NCT ID: NCT01440972 Completed - Knee Osteoarthritis Clinical Trials

Assessment of Efficacy of Low Intensity Resistance Training in Women at Risk for Symptomatic Knee Osteoarthritis

PBFR2
Start date: September 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to asses the efficacy of a 4 week low-intensity resistance training program with concurrent application of partial blood flow restriction (PBFR) to the exercising limbs to improve quadriceps strength and size, leg muscle power, and mobility in women at risk for developing symptomatic knee osteoarthritis. The primary outcome will be change in isotonic double leg-press 1 repetition maximum (1RM) strength. The investigators will test the following hypotheses. In comparison with low-intensity resistance training without use of PBFR, a four-week low-intensity resistance-training program with PBFR will: Primary Hypothesis: Increase (a) double leg-press 1RM strength and (b) isokinetic knee extensor strength Secondary Hypotheses: 1. Increase quadriceps muscle volume assessed by MRI 2. Increase lower limb muscle power on (a) double leg-press at 40% 1RM and (b) a timed stair climb 3. Not adversely effect knee pain or quality of life assessed by the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire

NCT ID: NCT01311206 Completed - Knee Osteoarthritis Clinical Trials

Low Intensity Resistance Training With Partial Blood Flow Restriction for Quadriceps Strengthening

PBFR
Start date: February 2011
Phase: N/A
Study type: Interventional

The objective of the proposed research is to assess the efficacy of an eight-week, efficient and tolerable, low-intensity resistance-training program with concurrent application of partial blood flow restriction (PBFR) for improving quadriceps strength and volume in women with risk factors for incident symptomatic or progressive knee OA. This specific aim will be achieved through a randomized, controlled trial, comparing low intensity training with and without PBFR. There have been numerous reports of exercise interventions in people with knee osteoarthritis. However, this research is novel in that it will be the first to use a low intensity regimen that will minimize forces on the knee while still having the potential to lead to clinically meaningful strength gains in older adults with risk factors for incident symptomatic or progressive knee OA.