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Clinical Trial Summary

The purpose of this study is to determine if physiologic pacing will improve symptoms and outcomes in patients with symptomatic first-degree heart block (pr interval ≥250ms).


Clinical Trial Description

The purpose of this study is to determine if physiologic pacing will improve symptoms and outcomes in patients with symptomatic first-degree heart block (pr interval ≥250ms). Patient will undergo a comparative effectiveness study where patients with symptomatic first-degree heart block (pr interval ≥250ms) undergo left bundle pacing (3830 lead) and are randomized to DDD-50 vs Managed Ventricular pacing-50 (MVP-50; AAI-DDD 50) and undergo a crossover at 3 months. This study will compare two standard of care options utilizing Food and Drug Administration (FDA) approved devices. Patients are evaluated at baseline, 3 months, and 6 months in terms of patient symptoms, exercise capacity, arrhythmia burden, and patient activity. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06245304
Study type Interventional
Source Ascension Health
Contact Daniel Kaiser, MD
Phone 6153295144
Email daniel.kaiser@ascension.org
Status Recruiting
Phase N/A
Start date October 1, 2023
Completion date June 30, 2025