Investigation of Biomarkers in Susac Syndrome

Susac Syndrome Clinical Trial

Official title:

Investigation of Relevant Biomarkers in Patients With Susac Syndrome

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01273792
• Other study ID #: Biomarkers Susac Syndrome
• Status: Recruiting
• Start date: May 2010
• Est. completion date: December 2021

Study information

• Verified date: July 2021
• Source: Charite University, Berlin, Germany
• Contact: Jan M Dörr, MD
• Phone: +49 30 450
• Email: jan-markus.doerr[@]charite.de
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Susac Syndrome is a rare disease and the establishment of the diagnosis is often difficult. The aim of this investigation is to identify relevant biomarkers and to elucidate the pathogenesis of Susac syndrome

Description:

Susac Syndrome is a rare disease characterized by encephalopathy, branch retinal artery occlusion and sensorineural deafness. The pathogenesis is not yet clear, an autoimmune endotheliopathy is discussed. Because of the variable and often incomplete clinical presentation, the establishment of the diagnosis is often delayed or even completely missed.

The aim of this study is to identify biomarkers that facilitate the reliable and prompt establishment of the diagnosis. Patients with a definite diagnosis of Susac syndrome and healthy subjects as controls are investigated.

Furthermore, the correlation of serological markers with structural retinal and cerebral changes will contribute to clarification of the pathogenesis of Susac syndrome.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: December 2021
• Est. primary completion date: December 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• adult male and female patients with definite Susac syndrome or matching healthy control subjects

• ability to provide informed consent

Exclusion Criteria:

• pregnancy

Related Conditions & MeSH terms

• Susac Syndrome
• Syndrome

Locations

Country	Name	City	State
Germany	NeuroCure Clinical Reserach Center, Charité Universitaetsmedizin	Berlin

Sponsors (1)

Lead Sponsor	Collaborator
Charite University, Berlin, Germany

Country where clinical trial is conducted

Germany, 

References & Publications (1)

Dörr J, Radbruch H, Bock M, Wuerfel J, Brüggemann A, Wandinger KP, Zeise D, Pfueller CF, Zipp F, Paul F. Encephalopathy, visual disturbance and hearing loss-recognizing the symptoms of Susac syndrome. Nat Rev Neurol. 2009 Dec;5(12):683-8. doi: 10.1038/nrneurol.2009.176. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	disease specific patterns of pathology on cranial MRI	one-time cranial MRI
Primary	disease specific patterns of pathology in optical coherence tomography	one time optical coherence tomography
Primary	serological biomarkers		not defined, cross-sectional analysis