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Clinical Trial Summary

This study describes Cefazolin pharmacokinetics variation to target levels during liver transplantation.


Clinical Trial Description

Cefazolin is one of the many drugs used in antibiotic prophylaxis during liver transplantation. However there are no study describing its pharmacokinetics during liver transplantation. Due to the severe pharmacokinetics interactions caused by both prior hepatopathy and surgical techniques we suppose that Cefazolin blood levels are very different from those targeted for antibiotic prophylaxis. This study aim to describe pharmacokinetics of Cefazolin during liver transplantation in order to adapt antibiotic prophylaxis strategy in case of unadapted measured levels. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04280237
Study type Observational
Source University Hospital, Tours
Contact
Status Withdrawn
Phase
Start date March 2020
Completion date March 18, 2020

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