Head Elevation During Pre-oxygenation Can Delay Desaturation Time

Surgery Clinical Trial

Official title:

Head Elevation During Pre-oxygenation Can Delay Desaturation Time in Indonesian Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05688722
• Other study ID #: IndonesiaUAnes913
• Status: Completed
• Phase: N/A
• Start date: April 1, 2021
• Est. completion date: May 31, 2021

Study information

• Verified date: January 2023
• Source: Indonesia University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study is a randomized-controlled trial study comparing the association between several degree of head elevation and conventional position during pre-oxygenation to desaturation time in patients undergo endotracheal intubation with general anesthesia

Description:

Preoxygenation anesthesia induction is an important part of airway management to reduce the risk of hypoxemia when the patient is apneic. The effectivity of preoxygenation is influenced by several things such as patient's head position. This study aimed to compare preoxygenation with head elevation 20°, 30° and 45° and conventional position to the time of desaturation before endotracheal intubation in patients undergoing general anesthesia. This was a randomized clinical trial of 56 patients, divided into four groups (conventional or 0° head elevation group, 20° head elevation group, 30° head elevation and 45° head elevation group). All subject was preoxygenated for 3 minutes with 100% oxygen. Induction of anesthesia was started with fentanyl, propofol, followed by rocuronium after the patient lost consciousness. Time was recorded from the start of induction until the oxygen saturation showed 93% or a time limit of 5 minutes. There was a significant difference in mean desaturation time among the four groups (p = 0.011). The most significant different was in 45o head elevation group (p < 0.05). . In patients undergoing general anesthesia, pre-oxygenation with head elevation 20°, 30° and 45° slows down the time for desaturation before endotracheal intubation compared to the conventional position. The 45° head elevation has the best result.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 56
• Est. completion date: May 31, 2021
• Est. primary completion date: May 31, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• undergo endotracheal intubation with general anesthesia for elective surgery

• aged 18-60 years old

• ASA physical status 1-2 preoperatively

Exclusion Criteria:

• Patients with difficult airway, cardiopulmonary disease, anemia, grade II obesity, pregnant, history of hypersensitivity to induction agents

• Patients did not give consent to follow the study

Related Conditions & MeSH terms

• Apnea
• Desaturation of Blood
• Surgery

Intervention

Procedure:
• Supine position
Patients preoxygenated in supine position before endotracheal intubation
• 20 degree head elevation position
Patients preoxygenated in 20 degree head elevation position before endotracheal intubation
• 30 degree head elevation position
Patients preoxygenated in 30 degree head elevation position before endotracheal intubation
• 45 degree head elevation position
Patients preoxygenated in 45 degree head elevation position before endotracheal intubation

Locations

Country	Name	City	State
Indonesia	Cipto Mangunkusumo Central National Hospital	Jakarta Pusat	DKI Jakarta

Sponsors (1)

Lead Sponsor	Collaborator
Indonesia University

Country where clinical trial is conducted

Indonesia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Desaturation time	Time was recorded from the start of induction until the oxygen saturation showed 93% or a time limit of 5 minutes	Right after induction until reach oxygen saturation 93% or 5 minutes time limit