Surgery Clinical Trial
Official title:
Is Regional Oxygen Saturation Effective in Predicting Perfusion Parameters and Patient Outcomes in Liver Resection
Sudden hypotension, which may develop during liver resection operations performed under general anesthesia, can affect the patient satisfaction at a high rate by causing complications during and after the operation as a result of disrupting the blood supply of the tissues. Although there are standard monitoring methods such as blood pressure, heart rate, and oxygen status that show unwanted hypotension during anesthesia, it is possible to show hypotension in the early period with new generation methods. Although there are many clinical studies proving the effectiveness of these methods, these methods have not yet been included in the standard monitoring methods. Our prediction in this study is that the development of intraoperative and postoperative complications in patients who will undergo liver surgery, in whom tissue blood flow is monitored with the help of devices, will be less than in patients who are followed up with traditional methods. If an individual participate in this study, he will not be subjected to any additional procedures other than routine practice during the participant's operation. Before standard general anesthesia for his surgery, heart rate, oxygenation status, blood pressure parameters will be monitored. After the initiation of general anesthesia, the procedures performed in each liver surgery will be applied. In addition, he will be followed by using a probe that allows monitoring of tissue blood flow and reflects a value to the screen, to which it is attached, by simply sticking to his skin.
Status | Recruiting |
Enrollment | 60 |
Est. completion date | March 20, 2022 |
Est. primary completion date | March 15, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: - patients with ASA I-III physical status patients between the ages of 18-75 patients who will undergo liver resection Exclusion Criteria: - patients with ASA physical status of IV patients with clinically significant cardiovascular, respiratory, renal or metabolic disease, ischemic cerebrovascular disease Patients who have BMI >30 Patients who aged >75 years Patients with intellectual disability Patients who will have intraoperative surgical complications Patients who will need for postoperative ventilation Patients who have methemoglobinemia after intravascular dye injection |
Country | Name | City | State |
---|---|---|---|
Turkey | Marmara University | Istanbul |
Lead Sponsor | Collaborator |
---|---|
Marmara University |
Turkey,
Brazy JE, Lewis DV, Mitnick MH, Jöbsis vander Vliet FF. Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observations. Pediatrics. 1985 Feb;75(2):217-25. — View Citation
Nardi O, Zavala E, Martin C, Nanas S, Scheeren T, Polito A, Borrat X, Annane D. Targeting skeletal muscle tissue oxygenation (StO(2)) in adults with severe sepsis and septic shock: a randomised controlled trial (OTO-StS Study). BMJ Open. 2018 Mar 19;8(3):e017581. doi: 10.1136/bmjopen-2017-017581. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Hepatic and renal tissue oxygenation | we will evaluate the effects of hepatic and renal StO2 measurement on early hypoperfusion and postoperative survival in hepatectomy cases, and peripheral tissue oxygen saturation measurement with StO2 InSpectra Tissue Spectrometer Model 1615 probe (Hutchinson Technology Inc. Hutchinson, MN, USA) and O3TM Regional Oximeter System ( We aimed to observe by doing it with O3 System, Masimo Corporation, Irvine, CA) devices. | baseline STO2 and O3 measurements at the beginning of the operation | |
Primary | Hepatic and renal tissue oxygenation | we will evaluate the effects of hepatic and renal StO2 measurement on early hypoperfusion and postoperative survival in hepatectomy cases, and peripheral tissue oxygen saturation measurement with StO2 InSpectra Tissue Spectrometer Model 1615 probe (Hutchinson Technology Inc. Hutchinson, MN, USA) and O3TM Regional Oximeter System ( We aimed to observe by doing it with O3 System, Masimo Corporation, Irvine, CA) devices. | STO2 and O3 measurements at the end of the operation | |
Primary | Hepatic and renal tissue oxygenation | we will evaluate the effects of hepatic and renal StO2 measurement on early hypoperfusion and postoperative survival in hepatectomy cases, and peripheral tissue oxygen saturation measurement with StO2 InSpectra Tissue Spectrometer Model 1615 probe (Hutchinson Technology Inc. Hutchinson, MN, USA) and O3TM Regional Oximeter System ( We aimed to observe by doing it with O3 System, Masimo Corporation, Irvine, CA) devices. | STO2 and O3 measurements at 24th hour postoperatively | |
Secondary | age | If hepatic and renal StO2 measurement on early hypoperfusion will be affected by age, anatomical region, ASA physical condition, whether it will be affected by the vascular clamp duration and its correlation with the risk of developing postoperative complications. | at 24th hour postoperatively | |
Secondary | ASA status | If hepatic and renal StO2 measurement on early hypoperfusion will be affected by age, anatomical region, ASA physical condition, whether it will be affected by the vascular clamp duration and its correlation with the risk of developing postoperative complications. | at 24th hour postoperatively | |
Secondary | Vascular clamp duration | If hepatic and renal StO2 measurement on early hypoperfusion will be affected by age, anatomical region, ASA physical condition, whether it will be affected by the vascular clamp duration and its correlation with the risk of developing postoperative complications. | Intraoperative duration of vascular clamp (minute) |
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