Mortality Score in Elderly Patients With Colon Cancer

Surgery Clinical Trial

— MECC  

Official title:

Score for the Prediction of Mortality Risk After Surgery for Colon Cancer in a Case Series of Elderly Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04538404
• Other study ID #: MECC Score
• Status: Completed
• Start date: January 1, 2011
• Est. completion date: January 31, 2019

Study information

• Verified date: August 2020
• Source: University of Bologna
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

CR-POSSUM is one of the most used surgical scores to predict mortality after colorectal surgery. Its main drawback is the requirement of intraoperative variables, whose collection is time-consuming and prevents from obtaining a purely preoperative risk assessment. The primary aim of the study is to develop a new surgical score using preoperative parameters to predict 30-day mortality after colon cancer surgery in the elderly population. The secondary objective is to analyze its efficacy compared to CR-POSSUM.

Description:

Patients aged 80 and older undergoing surgery for colon cancer from 2011 to 2017 in an Italian hospital were retrospectively selected. MECC score [Mortality in Elderly patients with Colon Cancer] was calculated summing up the scores relating to: arterial saturation of O2, Systolic Blood Pressure, Heart Rate, WBCs, Albumin, Creatinine. Once CR-POSSUM was calculated, the two scores were compared.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 385
• Est. completion date: January 31, 2019
• Est. primary completion date: August 31, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 80 Years and older

Eligibility

Inclusion Criteria:

• Patients aged 80 and above having elective and emergency colonic resection for colon cancer via open, laparoscopic and converted approaches

Exclusion Criteria:

• Surgical resections for rectal cancer and surgical procedures for non-neoplastic colon pathologies

Related Conditions & MeSH terms

• Colon Cancer
• Colonic Neoplasms
• Mortality
• Surgery

Intervention

Procedure:
• Colon Surgery
Right, left colon surgery, transverse colon surgery, multiple colon surgery in open and minimally invasive surgert

Locations

Country	Name	City	State
Italy	Bruno Nardo	Bologna
Italy	Marialuisa Lugaresi	Bologna

Sponsors (1)

Lead Sponsor	Collaborator
University of Bologna

Country where clinical trial is conducted

Italy, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	New surgical score using preoperative parameters to predict 30-day mortality after colon cancer surgery in the elderly population	MEC Score (arterial saturation of O2, Systolic Blood Pressure, Heart Rate, WBCs, Albumin, Creatinine) for the evaluation of the risk of in-hospital mortality occurred during hospitalization up to 30 days	Up to 30 days after surgery