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Clinical Trial Summary

Bone reconstruction in critical sized defect (CSD) remains a real challenge in orthopedic surgery in children and adults. The Masquelet technique is an innovative therapeutic technique, which offers a bone reconstruction in two steps, by the formation of an induced membrane (IM) around a polymethylmethacrylate (PMMA) spacer placed into the bone defect. After, PMMA removal, the cavity is filled with corticocancellous graft allowing bone healing. Up to date, all angiogenesis and osteogenic properties of IM remain unknown. The purpose of this study is to characterize angiogenesis and osteogenic properties of IM in children and adults.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04246944
Study type Interventional
Source Centre Hospitalier Universitaire, Amiens
Contact Céline Klein, MD
Phone (33)322087571
Email klein.celine@chu-amiens.fr
Status Recruiting
Phase N/A
Start date May 23, 2019
Completion date January 2030

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