Surgery Clinical Trial - NO During CPB in Neonates to Reduce Risk of AKI

Status Recruiting

Clinical Trial Summary

Acute kidney injury (AKI) following cardiac surgery for congenital heart defects (CHD) in children affects up to 60% of high risk-patients and is a major cause of both short- and long-term morbidity and mortality. Despite effort, to date, no successful therapeutic agent has gained widespread success in preventing this postoperative decline in renal function. Nitric oxide is an intricate regulator of acute inflammation and coagulation and is a potent vasodilator. The investigators hypothesize that nitric oxide, administered during cardiopulmonary bypass (CPB), may reduce the incidence of AKI.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04216927
Study type	Interventional
Source	Children's Hospital Medical Center, Cincinnati
Contact	David S Cooepr, MD
Phone	5138035448
Email	David.Cooper@cchmc.org
Status	Recruiting
Phase	Phase 3
Start date	January 10, 2023
Completion date	June 1, 2025

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