Surgery Clinical Trial
Official title:
The Influence of Nursing Technique Applied at the Central Venous Catheter Insertion Site Upon the Incidence of Infection
Assessing the impact of the nursing technique applied at the insertion site of the central venous catheter using hydrophilic methacrylate gel (HMG) and 2% Chlorhexidine (CHG) upon the incidence of inflammatory complications when treating the surrounding of the central venous catheter.
The study was a prospective and randomized clinical trial. The study was performed at two
departments of the University Hospital Ostrava.
The design and performance of the study were approved by the Ethics Committee of the
University Hospital Ostrava.
The patients indicated for insertion of central venous catheter (CVC) were informed about the
possible nursing techniques applied at the insertion site of the central venous catheter,
participation in the study was conditioned with signing a written informed consent. The study
evaluated the superiority of a new procedure in providing nursing care for patients with CVC.
Basic patient characteristics were observed and recorded according to the protocol of the
study (age, sex, diagnosis), the number of days with CVC inserted, type of dressing, APACHE
II score, the presence of neutropenia and the final score of assessment of local signs of
inflammation, which was defined as follows:
0 points = No reddening
1. point = Reddening below 2 mm in diameter around the incision
2. points = Reddening below 5 mm in diameter around the incision
3. points = Reddening exceeding 5 mm in diameter around the incision
4. points = Purulent secretion, swelling, pain
5. points = Catheter sepsis The investigators also recorded the day when the first signs of
local infection were observed.
The obtained results were evaluated with standard statistical techniques (Chí-quadrate test,
Fisher's exact test).
Upon inserting CVC, the type of draping was recorded (small, middle, large), and the
cannulated vein (vena subclavia, left and right, vena jugularis interna, left and right, vena
femoralis, left and right). A smear was obtained from around the incision site in all
patients after insertion and after extraction; the smears were sent for microbiology
cultivation and determination of sensitivity to antibiotic therapy. Changing of the dressings
was performed in accordance with standard operating procedures of the University Hospital
Ostrava. The CVC was attended under aseptic conditions, using sterile material. Surrounding
of CVC was mechanically cleaned and disinfected using 2% chlorhexidine for disinfection of
the skin, let to dry, and semipermeable foil was placed at the site, containing chlorhexidine
gluconate. The dressing was identified with a date when it was applied. This was left in situ
for 3-4 days, and the procedure was repeated.
The patients were randomized into two study groups:
1. HMG Group - the patients were treated with 2% chlorhexidine for skin disinfection, HMG
and transparent foil
2. CHG Group - the patients were treated with 2% chlorhexidine for skin disinfection and
dressing with CHG The randomization procedure further divided the patients into two
study arms
1. Neutropenia Group (defined as the number of neutrophil granulocytes below 1x109/l 2.
No-neutropenia Group (with a normal number of neutrophil granulocytes
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