Surgery Clinical Trial
— TWISTlungOfficial title:
EMT, Reactivation of Embryonic Transcription Factors and Alteration of the miR Signaling Network as Pronostic and Predictive Markers in Lung Cancer
The goal of the present research is to identify an "EMT signature", associated with long term disease-free survival after surgery in NSCLC. This study will potentially lead to specific treatment recommendations, thanks to an integrated molecular approach including DNA, RNA and miR profiling In vitro analyses using lung cancer cell lines will subsequently be conducted to validate markers identified in tumor screenings.
Status | Recruiting |
Enrollment | 1000 |
Est. completion date | December 31, 2025 |
Est. primary completion date | March 31, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 100 Years |
Eligibility |
Inclusion Criteria: - Patient with NSCLC stage I II IIIA IIIB, treated by surgery at Georges Pompidou Hospital (HEGP) Informed consent ONCOHEGP signed Exclusion Criteria: - Informed consent ONCOHEGP not signed |
Country | Name | City | State |
---|---|---|---|
France | Aphp Hegp | Paris |
Lead Sponsor | Collaborator |
---|---|
European Georges Pompidou Hospital | APHP |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Relapse free survival | Time to relapse after surgery | 1 year | |
Primary | Overall survival | Time to death | 5 years | |
Secondary | Overall survival | Time to death | 3 years |
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