Surgical Admission at the Weekend and 30-day Mortality in Ontario, Canada: a Matched Cohort Study

Surgery Clinical Trial

Official title:

The Association Between Weekend Admission and Perioperative Adverse Outcomes for Adults Undergoing Surgery: A Matched Cohort Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03268044
• Other study ID #: 1000055744
• Status: Recruiting
• Start date: October 18, 2016
• Est. completion date: September 15, 2018

Study information

• Verified date: May 2018
• Source: The Hospital for Sick Children
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Surgery is performed at the weekend for risk to life or limb, when mandated by clinical guidelines, or depending on resource availability. Weekend healthcare interventions have been associated with increased mortality and adverse clinical outcomes in the majority of the literature examining the weekend effect, but these findings are not consistent. Results from recent observational studies argue against a true weekend effect. Higher rates of adverse outcomes associated with hospital activity at weekends do not appear to be due to altered medical staffing as commonly hypothesized, but are thought to be in part a result of data artefact and confounding by severity or indication. For this study, we hypothesized that patients who are admitted to hospital at the weekend and require surgery have an increased risk of death compared with patients who are admitted and undergo surgery on weekdays. The primary aim was to examine whether patients who underwent surgery and were admitted at the weekend had an increased risk of 30 day all-cause mortality compared with patients who were admitted and underwent surgery on weekdays; secondary aim was to examine whether the timing of surgery (i.e., surgery on the same weekend or surgery on a subsequent weekday) for patients admitted at the weekend is associated with increased risk of 30 day all-cause mortality.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 340000
• Est. completion date: September 15, 2018
• Est. primary completion date: September 15, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• any hospital admission associated with an eligible surgical procedure in the Ontario discharge abstract database

• between 2005 and 2015

Exclusion Criteria:

• cardiothoracic or cardiology therapeutic procedures

• non-surgical therapeutic interventions (e.g. dialysis)

• obstetric procedures.

Related Conditions & MeSH terms

• Surgery

Intervention

Other:
• Hospital admission and surgery
Hospital admission and noncardiac surgery

Locations

Country	Name	City	State
Canada	The Hospital for Sick Children	Toronto	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
The Hospital for Sick Children

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	30 day all cause mortality	death	30 days from surgery