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Target Attainment and Pharmacokinetics of Antimicrobials in Non-critically Ill Surgery Patients (TAPAS) — TAPAS  

Surgery Clinical Trial

Official title:
Target Attainment and Pharmacokinetics of Antimicrobials in Non-critically Ill Surgery Patients

Clinical Trial Summary

In this prospective observational study, the investigators want to document pharmacokinetic/pharmacodynamic (PK/PD) target attainment of frequently used antimicrobials in an adult non critically ill surgery population (abdominal surgery, traumatology and septic orthopedic surgery). Furthermore, the investigators want to identify risk factors for not attaining predefined PK/PD targets.

The antibiotics of interest are amoxicillin(-clavulanic acid), flucloxacillin, piperacillin-tazobactam, meropenem and clindamycin.

Clinical Trial Description

In this research proposal, the primary objective is to describe PK parameters (area under the curve (AUC), clearance (Cl), distribution volume (Vd) and half life (T1/2)) for the antibiotics of interest (amoxicillin(-(clavulanic acid), flucloxacillin, piperacillin-tazobactam, meropenem and clindamycin) for this adult non critically ill surgery population.

Besides, the investigators want to document pharmacokinetic/pharmacodynamic (PK/PD) target attainment of frequently used ABs in this population and to identify risk factors, for example augmented renal clearance (ARC), for not attaining predefined PK/PD targets. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03120663
Study type Observational
Source Universitaire Ziekenhuizen Leuven
Contact Peter Declercq, PharmD
Phone 003216342340
Email peter.declercq@uzleuven.be
Status Recruiting
Phase N/A
Start date November 30, 2016
Completion date September 30, 2018
View Details
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