Processed Residual Pump Blood in Cardiac Surgery: The PRBC Trial — PRBC  

Surgery Clinical Trial

Official title: Processed Residual Pump Blood in Cardiac Surgery: The PRBC Trial

Status Completed

Clinical Trial Summary

The study is an randomized controlled trial (RCT) of 198 coronary artery bypass graft (CABG) patients, exploring whether ultrafiltration of residual blood in the cardiopulmonary bypass circuit reduces transfusion and bleeding.

Clinical Trial Description

Blood products are a limited resource and cardiac surgery is a high consumer. Processing residual cardiopulmonary bypass (CPB) volume via ultrafiltration may improve hemostasis and reduce transfusion through clearing activated complement, activated coagulation components, and proinflammatory cytokines. Unlike cell saver technology, ultrafiltration has the advantage of maintaining plasma proteins, platelets, and coagulation factors. We sought to establish if the processing of residual CPB volume with ultrafiltration reduces homologous blood transfusion and bleeding. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Cardiopulmonary Bypass
• Hemorrhage
• Surgery

• NCT number: NCT01173822
• Study type: Interventional
• Source: McMaster University
• Status: Completed
• Phase: N/A
• Start date: December 2004
• Completion date: April 2007