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Supine Hypertension clinical trials

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NCT ID: NCT05489575 Recruiting - Parkinson Disease Clinical Trials

CPAP for the Treatment of Supine Hypertension

Start date: June 23, 2022
Phase: N/A
Study type: Interventional

This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their high blood pressure during the night. CPAP (a widely used treatment for sleep apnea) involves using a machine that blows air into a tube connected to a mask covering the nose, or nose and mouth, to apply a low air pressure in the airways. The study includes 3-5 days spent in the Vanderbilt Clinical Research Center (CRC): at least one day of screening tests, followed by up to 3 study days. Subjects may be able to participate in daytime and/or overnight studies. The Daytime study consists of 2 study days: one with active CPAP and one with sham CPAP applied for up to 2 hours. The Overnight study consists of 3 study nights: one with active CPAP, one with sham CPAP, both applied for up to 9 hours and one night sleeping with the bed tilted head-up.

NCT ID: NCT04502225 Recruiting - Autonomic Failure Clinical Trials

Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure

Start date: August 21, 2020
Phase: N/A
Study type: Interventional

Many persons with autonomic failure often have high blood pressure when lying down (supine hypertension). This study is exploring the impact of decreased venous return to the heart (achieved by raising the head of the bed) to lessen supine blood pressure. If decreased venous return to the heart is effective at lowering supine blood pressure, these approaches may be utilized to treat supine hypertension non-pharmacologically. Raising the head of the bed decreases the amount of blood returning to the heart due to the effects of gravity. In this case, the decreased blood return to the heart may decrease blood pressure.

NCT ID: NCT03312556 Recruiting - Autonomic Failure Clinical Trials

Treatment of Supine Hypertension in Autonomic Failure (CPAP)

Start date: September 21, 2017
Phase: N/A
Study type: Interventional

Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe and complicates the treatment of orthostatic hypotension. The purpose of this study is to assess whether continuous positive airway pressure (CPAP) decreases blood pressure in autonomic failure patients with supine hypertension.