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Sun Damaged Skin clinical trials

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NCT ID: NCT05926791 Completed - Sun Damaged Skin Clinical Trials

Photoprotective Effects of a SPF50+ Sunscreen on Skin Genotoxicity Induced by Repeated Chronic Outdoor Sun Exposure

Start date: June 28, 2021
Phase:
Study type: Observational

Between 2 and 3 million non-melanoma skin cancers and 132,000 melanoma skin cancers occur globally each year. Sun protection continues to be a major public health issue and has always been a priority research area for Pierre Fabre laboratories. The involvement of ultraviolet radiation of the solar spectrum in skin carcinogenesis is well known, through its ability to damage the DNA of skin cells and the induction of oxidative processes. The aim of this exploratory study is to perform the quantification of: - DNA photoproducts excised from the genome by the biological repair systems in urine samples - cellular DNA damage in the epidermis following chronic exposure to natural sunlight. This study will allow us to better understand and quantify the benefit of sunscreens on photoinduced cellular damage and their elimination in urine.

NCT ID: NCT05865431 Completed - Sun Damaged Skin Clinical Trials

Singlet Oxygen Quantification After Skin Exposure to Ultraviolet A (UVA) Light

Start date: March 17, 2017
Phase: N/A
Study type: Interventional

The objective of this study is quantification of singlet oxygen species in the skin after exposure to Ultraviolet A (UVA) light

NCT ID: NCT05398237 Completed - Sun Damaged Skin Clinical Trials

An Assessment of TLR4 and TOPK/PRPK Signaling in Sun Damaged Human Skin Acutely Exposed to Solar Simulated Light

Start date: February 3, 2020
Phase: N/A
Study type: Interventional

The purpose of this project is to obtain clinical data, including skin samples, that will help investigators evaluate changes occurring in sun damaged human skin as a result of light that simulates sun exposure (Solar Simulated Light). Of specific interest are the molecular targets for cancer prevention. Molecular targets are the parts of the body's cells that have been shown to play a role in causing or preventing cancer and which scientists seek to affect in a way that may slow or eliminate the development of cancer.

NCT ID: NCT05300542 Completed - Erythema Clinical Trials

Efficacy Study of a Novel Skin Health Product to Reduce an UVB Induced Erythema

Start date: March 17, 2022
Phase: N/A
Study type: Interventional

The aim of this study is to determine the erythema-reducing efficacy of a test product in two concentrations on a light sunburn induced by a sun simulator compared to an untreated control and a placebo product.

NCT ID: NCT05162300 Completed - Wrinkle Clinical Trials

Same-Day Combination of VI Peel and Botox for Correction of Sun Damage, Fine Lines and Wrinkles

Start date: December 8, 2021
Phase: Phase 4
Study type: Interventional

This study is being conducted to improve standards of care in the cosmetic treatment of sun damage, fine lines, and wrinkles. VI Peels® and Botox® have been used cosmetically to improve patient concerns as monotherapies. This study seeks to confirm that the same-day combination creates no additional side-effects and furthermore that patient satisfaction is heightened as a result.

NCT ID: NCT04181476 Active, not recruiting - Sun Damaged Skin Clinical Trials

Efficacy Evaluation of Products Against Long Wavelength Ultraviolet A1 and Visible Light Induced Biological Effects

Start date: November 5, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy of topical products in providing protection against the visible light and ultraviolet A1 (UVA1) part of sunlight. Ultraviolet radiation and visible light are both components of sunlight that reach the earth. It is important to test these topical products against visible light and UVA1 because our current sunscreens may not protect against these very well.

NCT ID: NCT03110159 Completed - Skin Cancer Clinical Trials

DUSA: Cyclic PDT for the Prevention of AK & NMSC in Solid Organ Transplant Recipients

Start date: August 29, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

This is a pilot, phase 2, prospective, comparative study to evaluate the safety and efficacy of the combination of Levulan® Kerastick® for Topical Solution and blue light illumination using the BLU-U® Blue Light Photodynamic Therapy Illuminator (LevulanPDT). The study hypothesis is that post solid organ transplantation patients, highly susceptible to non-melanoma skin cancer, can be treated safely and effectively through clinical cyclic application of PDT, lessening morbidity and possible mortality for this immunosuppressed patient population.

NCT ID: NCT03007589 Enrolling by invitation - Sunburn Clinical Trials

Natural Sunlight Protection and Simulated Sunlight Protection Offered by Sunscreens and Fabrics

Start date: April 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to assess how human skin reacts and how sunscreens and sun protection fabrics protect in natural sunlight compared to their labeled claims, indoor testing methods (existing or modified) and instructions.

NCT ID: NCT03006185 Completed - Actinic Keratosis Clinical Trials

Laser and Microdermabrasion Before Photodynamic Therapy for Actinic Keratoses in Field-cancerized Skin

Start date: August 2016
Phase: Phase 2
Study type: Interventional

Comparison of treatment efficacy and safety of pretreatment with ablative fractional laser versus microdermabrasion combined with large-area photodynamic therapy with methyl aminolevulinate for actinic keratoses

NCT ID: NCT00440024 Completed - Sun-Damaged Skin Clinical Trials

The Effect Of A Controlled Daily Skin Care Regimen On Retinoic Acid Tolerance

Start date: February 2007
Phase: N/A
Study type: Interventional

Sun-damaged skin, caused by chronic exposure to ultraviolet (UV) light, is characterized by features such as wrinkling, uneven skin color, roughness and brown spots. An effective treatment for sun-damage that is commonly prescribed is topical retinoic acid (RA). However, the major drawback of topical RA use has been frequently observed irritation characterized by redness, dry skin and severe itching. In this study, we examine whether a daily skin care regimen comprised of an ultra mild cleanser and an effective moisturizer can help improve tolerance to RA treatment.