Retinoid Intolerance Clinical Trial
Official title:
A Single-Blind Study to Assess Benefits of a Controlled Daily Skin Care Regimen on Retinoid Intolerant Patients (Derm 570)
Sun-damaged skin, caused by chronic exposure to ultraviolet (UV) light, is characterized by features such as wrinkling, uneven skin color, roughness and brown spots. An effective treatment for sun-damage that is commonly prescribed is topical retinoic acid (RA). However, the major drawback of topical RA use has been frequently observed irritation characterized by redness, dry skin and severe itching. In this study, we examine whether a daily skin care regimen comprised of an ultra mild cleanser and an effective moisturizer can help improve tolerance to RA treatment.
Sun-damaged skin, caused by chronic exposure to ultraviolet (UV) light, is characterized by
features such as wrinkling, uneven skin color, roughness and brown spots. An effective
treatment for sun-damage that is commonly prescribed is topical retinoic acid. However, the
major drawback of topical retinoic acid use has been frequently observed irritation
characterized by redness, dry skin and severe itching. In this study, we examine whether a
daily skin care regimen comprised of an ultra mild cleanser and an effective moisturizer can
help improve tolerance to retinoid treatment.
Subjects for whom retinoid treatment is indicated for sun-damage will be recruited into the
study. The retinoid intolerance will be established via prior history (detailed
questionnaire) and a 2-week retinoid treatment (Tazarotene 0.1% cream) phase followed by
clinical evaluation and determination of retinoid intolerance.
Subjects that exhibit retinoid intolerance will continue with the study. Approximately 30
subjects will be put on a controlled daily skin care regimen during the remainder of the
study period while the rest of the subjects will continue their normal skin care habits. The
controlled skin care regimen will consist of facial cleansing with a Dove ultra mild
emollient cleanser and application of Dove facial moisturizer, used as normal. During this
period, subjects will be evaluated to determine reduction of retinoid intolerance symptoms.
;