Heart Failure Clinical Trial
Official title:
Investigation of Myocardial Function and Vascular Adaptation in Association With Genotype in Marathon Runners
The purpose of the study is to determine the myocardial function and vascular adaptation after strenuous exercise in association with genotype/polymorphisms. We aim to investigate the effects of extreme endurance exercise on the cardiovascular system. Furthermore, the role of the inflammatory response and adaptive mechanisms of the vasculature are examined. Subclinical injuries to the myocardium and vascular wall are being investigated.
Regular exercise leads to an improvement of cardiovascular risc factors in patients with
coronary heart disease, atherosclerosis and metabolic disorders. Aerobic exercise has
anti-inflammatory effects. In contrast, the exertional exercise of marathon running causes
an acute pro-inflammatory impulse. This may lead to myocardial injury and, in case of
preexisting plaques, may result in plaque rupture and acute myocardial infarction.
We aim to define the critical role of inflammatory markers and cardiovascular risc factors
as a predictor of an increased risk for myocardial and endothelial dysfunction in marathon
runners.
Diagnostic tools include measurements of augmentation index (AIx), arteriolar-venular ratio
(AVR) and, for the first time, 2D and 3D echocardiographic measurements such as TDI-imaging
and speckle tracking. Inflammatory markers include c-reactive protein (CRP), interleukins
and tumor necrosis factor. Additionally, cardiovascular markers are measured. All variations
are analysed on the basis of genotype characteristics/polymorphisms.
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Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
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