Substance Use Disorders Clinical Trial
— Chess_SUDOfficial title:
Investigating Neurobiological Mechanisms of Chess as an Add-On Treatment Against Substance Use Disorder
Verified date | March 2024 |
Source | Central Institute of Mental Health, Mannheim |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Neurobiological and neuropsychological approaches to investigate the potential mechanism of action of chess as an add-on therapy (chess based - cognitive remediation treatment, CB-CRT) to reduce cognitive deficits in individuals with alcohol use disorder (AUD) or tobacco use disorder (TUD).
Status | Completed |
Enrollment | 108 |
Est. completion date | November 17, 2023 |
Est. primary completion date | November 17, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - severe alcohol (AUD) or tabacco use disorder (SUD) according to DSM-5 - abstinence from alcohol for at least 72 hours (AUD) - sufficient ability to communicate with investigators and answer questions in both written and verbal format - ability to provide fully informed consent and to use self-rating scales - main diagnosis AUD: inpatient or outpatient treatment in our clinic - main diagnosis TUD: participation in 6 weeks smoking cessation treatment - Normal or corrected to normal vision - Signed consents for data security Exclusion Criteria: - severe internal, neurological, and/or psychiatric comorbidities; other Axis I mental disorders other than TUD according to ICD-10 and DSM 5 (except for other substance use disorders - if AUD or TUD is still the main diagnosis -, ADHD, remitted depression, mild or moderate depression, adjustment disorder, generalized anxiety disorder, phobias, panic disorder or other mild or moderate personality disorders) in the last 12 months - Severe withdrawal symptoms (CIWA-Ar > 7; Sullivan et al. 1989) - alcohol intoxication (>0‰) - history of brain injury - severe cognitive impairments - common exclusion criteria for MRI (e.g. metal, claustrophobia, pregnancy) - suicidality or endangerment of others - positive Covid-19 screening |
Country | Name | City | State |
---|---|---|---|
Germany | Klinik für Abhängiges Verhalten, Zentralinstitut für Seelische Gesundheit | Mannheim |
Lead Sponsor | Collaborator |
---|---|
Central Institute of Mental Health, Mannheim |
Germany,
Adinoff B. Neurobiologic processes in drug reward and addiction. Harv Rev Psychiatry. 2004 Nov-Dec;12(6):305-20. doi: 10.1080/10673220490910844. — View Citation
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Atherton M, Zhuang J, Bart WM, Hu X, He S. A functional MRI study of high-level cognition. I. The game of chess. Brain Res Cogn Brain Res. 2003 Mar;16(1):26-31. doi: 10.1016/s0926-6410(02)00207-0. — View Citation
Bates ME, Buckman JF, Nguyen TT. A role for cognitive rehabilitation in increasing the effectiveness of treatment for alcohol use disorders. Neuropsychol Rev. 2013 Mar;23(1):27-47. doi: 10.1007/s11065-013-9228-3. Epub 2013 Feb 15. — View Citation
Blasco-Fontecilla H, Gonzalez-Perez M, Garcia-Lopez R, Poza-Cano B, Perez-Moreno MR, de Leon-Martinez V, Otero-Perez J. Efficacy of chess training for the treatment of ADHD: A prospective, open label study. Rev Psiquiatr Salud Ment. 2016 Jan-Mar;9(1):13-2 — View Citation
Demily C, Cavezian C, Desmurget M, Berquand-Merle M, Chambon V, Franck N. The game of chess enhances cognitive abilities in schizophrenia. Schizophr Res. 2009 Jan;107(1):112-3. doi: 10.1016/j.schres.2008.09.024. Epub 2008 Nov 7. No abstract available. — View Citation
Fattahi F, Geshani A, Jafari Z, Jalaie S, Salman Mahini M. Auditory memory function in expert chess players. Med J Islam Repub Iran. 2015 Oct 6;29:275. eCollection 2015. — View Citation
Fauth-Buhler M, de Rover M, Rubia K, Garavan H, Abbott S, Clark L, Vollstadt-Klein S, Mann K, Schumann G, Robbins TW. Brain networks subserving fixed versus performance-adjusted delay stop trials in a stop signal task. Behav Brain Res. 2012 Nov 1;235(1):89-97. doi: 10.1016/j.bbr.2012.07.023. Epub 2012 Jul 20. — View Citation
Goncalves PD, Ometto M, Bechara A, Malbergier A, Amaral R, Nicastri S, Martins PA, Beraldo L, dos Santos B, Fuentes D, Andrade AG, Busatto GF, Cunha PJ. Motivational interviewing combined with chess accelerates improvement in executive functions in cocain — View Citation
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Onofrj M, Curatola L, Valentini G, Antonelli M, Thomas A, Fulgente T. Non-dominant dorsal-prefrontal activation during chess problem solution evidenced by single photon emission computerized tomography (SPECT). Neurosci Lett. 1995 Oct 6;198(3):169-72. doi — View Citation
Vollstadt-Klein S, Wichert S, Rabinstein J, Buhler M, Klein O, Ende G, Hermann D, Mann K. Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum. Addiction. 2010 Oct;105(10):1741-9. doi: — View Citation
* Note: There are 12 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | change in neural alcohol cue-reactivity | fMRI alcohol cue-reactivity task (Vollstädt-Klein et al. 2010) | 2 time points: before and after 6 weeks chess-based cognitive training | |
Primary | change in neural tobacco cue-reactivity | fMRI tobacco cue-reactivity task (Vollstädt-Klein et al. 2011) | 2 time points: before and after 6 weeks chess-based cognitive training | |
Primary | change in neural correlates of inhibition | fMRI stop-signal task (Whelan et al. 2012) | 2 time points: before and after 6 weeks chess-based cognitive training | |
Primary | substance use (alcohol consumption and tabacco use) | self-report | 3 months follow-up after the end of treatment | |
Primary | change in neural working memory processes | fMRI working memory task "N-back" (Charlet et al. 2014) | 2 time points: before and after 6 weeks chess-based cognitive training | |
Primary | Change in working memory capacity | working memory capacity measured by letter-number sequencing task of the [Wechsler Memory Scale (Kent 2013)]; raw values will be transformed to IQ-like scales (mean 100, SD 15); the higher the value, the higher the working memory capacity | 2 time points: before and after 6 weeks SCP | |
Primary | Change in impulsivity | impulsivity measured with BIS scale [Barratt impulsiveness scale (Patton et al. 1995)];range 15-60; total score will be used; high values represent high impulsivity | 3 time points: before and after 6 weeks SCP plus after 3 months | |
Primary | Change in decision-making | [Iowa Gambling Task (Bechara et al. 1994)] | 2 time points: before and after 6 weeks SCP | |
Primary | Change in mental flexibility | [Dimensional Change Card Sort (Zelazo et al. 2014)] | 2 time points: before and after 6 weeks SCP | |
Primary | Change in attentional capacity | [d2 Test of Attention (Brickenkamp 2002)]. | 2 time points: before and after 6 weeks SCP | |
Secondary | change in functional connectivity within the salience network (SN) and executive control network (ECN) | [measured with fMRI] | 2 time points: before and after 6 weeks therapy and chess-based cognitive training |
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