Guanfacine to Improve Substance Use Outcomes in Women

Status Completed

Clinical Trial Summary

Hypothesis: Guanfacine (GUA) (3mg/day) will reduce drug craving, improve cognitive flexibility and result in associated lower drug use in women with substance use disorder (SUD) in an outpatient clinical setting.

Clinical Trial Description

This study proposes to extend previous Phase I experimental work to address the following specific aims: (1) assess GUA's target engagement of drug craving and cognitive flexibility in a laboratory challenge session and in a 10-week outpatient clinical study, (2) demonstrate target validation by showing that reduced drug craving and improved cognitive flexibility will predict lower drug use outcomes during the 10-week clinical trial in SUD women, and finally, (3) evaluate data replication and scalability of GUA target effects across two clinical sites (Yale and SUNY-Stony Brook). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03980184
Study type	Interventional
Source	Yale University
Contact
Status	Completed
Phase	Phase 2
Start date	November 1, 2019
Completion date	November 30, 2022

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