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SMART Brain Health in African-Americans — SMART  

Substance Use Disorders Clinical Trial

Official title:
A Systematic Medical Approach to Reward Transformation (SMART) for Brain Health in Opioid Use Disorder

Clinical Trial Summary

The investigators hypothesize that opioid use in African-Americans will be associated with hypodopaminergic alleles that alter the threshold for activating feelings of reward and pleasure within the dopaminergic system, and that these allelic frequencies will differ significantly from European Americans. Planned is a targeted system to study genetic risks for reward deficiency using risk gene panel to assign a genetic addiction risk score (GARS), comprehensive surveys to determine quality of life and exposure to stressors and trauma. This system will allow prediction of addiction and relapse potential and delivery of personalized treatment.

Clinical Trial Description

Individuals seeking treatment for Opioid Use Disorder in the Washington DC metro area will be recruited to this Study, which consists of 1) early pre-disposition diagnosis using the Genetic Addiction Risk Score (GARS); 2) Assessment of reward deficiency, co-morbid neuropsychiatric disease, quality of life/happiness, stressors/trauma and other psychometric measurements using validated questionnaires; Urine drug testing during actual treatment that uses comprehensive analysis of reported drugs to determine compliance with prescription medications and non-abstinence to illicit drugs; and 4) adjunctive treatment with neuroadaptogen amino acid therapy (NAAT), a glutaminergic-dopaminergic optimization nutraceutical (generic name: KB220) compared to placebo, aimed to prevent relapse by induction of dopamine homeostasis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03861832
Study type Interventional
Source Howard University
Contact Marjorie C. Gondré-Lewis, Ph.D.
Phone 202-806-5274
Email mgondre-lewis@Howard.edu
Status Recruiting
Phase N/A
Start date June 16, 2018
Completion date August 30, 2019
View Details
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