Substance Use Disorders Clinical Trial
Official title:
Addiction and Substance Dependence in Adolescence - Neurobiological Pathomechanisms and Treatment Evaluation
This study aims to investigate the sociodemographic background as well as psychiatric
comorbidities of adolescent substance users with substance use disorders. The study
simultaneously evaluates biomarkers of stress and addiction, including long-term cortisol
levels from hair samples and gene methylation in blood samples associated with substance use.
Our study also adapts, rolls out, and evaluates an evaluated multimodal treatment manual wich
was originally intended for stimulant drug users (MATRIX). We adopt this manual to the needs
and specifics of adolescents (MATRIX-A, A=adolescents) with substance use disorders of any
substance, including cannabis, methamphetamine, and alcohol. Adolescents will receive group
therapy sessions, individual therapy sessions, and medication if needed, while parents or
professional caretaker will receive group sessions. Therapy outcomes will be examined in
addition to parental distress and parenting skills.
As numbers of adolescent drug abuse have grown rapidly within the last couple of years,
research on youth drug abuse and dependency has taken a new and vital role within the public
healthcare system. For this reason, it is crucial to find new ways to effectively integrate
adolescent patients into the health care system, as well as assign them to treatment options
tailor made for the specific challenges and needs of this population. This study aims to
investigate (a) sociodemographic background and psychiatric comorbidities in connection with
adolescent substance abuse and dependence to enhance understanding of epidemiologic risk
factors for developing drug dependency in adolescence, as well as benefit future treatment
options.
It further aims to investigate (b) molecular and epigenetic mechanisms of addiction disorders
in adolescents by analyzing methylation pattern, as well as proteome analysis of peripheral
immune markers. The investigator's aim is a better understanding of the multimodal biological
underpinnings of risk/resilience for addiction in youth on the molecular, cellular and
circuit levels with a special focus on the changes within the stress and immune system in
patients with addiction disorders and their family members.
Another research interest of this study concerns (c) adapting and evaluating new treatment
options, tailor made for the adolescent population. For this reason the investigators aim to
adapt, implement and evaluate a therapeutic program according to the MATRIX manual for the
treatment of substance abuse, which consists of two group therapies for patients, as well as
their parents (Evaluation time points: T0, T1, and T2).
Last, this study aims to (d) evaluate parental stress levels, parental communication skills
and knowledge in connection with adolescent substance abuse.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05660434 -
Using Aromatherapy in Substance Use Disorder
|
N/A | |
| Active, not recruiting |
NCT05338268 -
Substance Use and Loneliness
|
N/A | |
| Completed |
NCT04098614 -
Barriers to Substance Use Disorder Recovery
|
N/A | |
| Completed |
NCT03954184 -
E-health Implementation (Iowa)
|
N/A | |
| Completed |
NCT03590106 -
Cardiac Surgery Peer Recovery Support Program
|
N/A | |
| Recruiting |
NCT05118204 -
Randomized Trial of Buprenorphine Microdose Inductions During Hospitalization
|
Phase 4 | |
| Recruiting |
NCT06273228 -
Parenting Young Children in Pediatrics
|
N/A | |
| Recruiting |
NCT05327504 -
Written Exposure Therapy for Veterans With SUD and PTSD
|
N/A | |
| Terminated |
NCT03517111 -
The Impact of a Parenting Intervention on Latino Youth Health Behaviors
|
N/A | |
| Completed |
NCT04284813 -
Families With Substance Use and Psychosis: A Pilot Study
|
N/A | |
| Completed |
NCT04401215 -
Technologically-Augmented Referrals to Mitigate Addiction Consequences
|
N/A | |
| Not yet recruiting |
NCT06187701 -
Co-Active Therapeutic Theatre (Co-ATT) for Dual-Diagnosis Patients
|
N/A | |
| Not yet recruiting |
NCT06163651 -
Evaluating a One-Year Version of the Parent-Child Assistance Program
|
N/A | |
| Recruiting |
NCT04296604 -
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
|
N/A | |
| Active, not recruiting |
NCT02382042 -
Intensive Referral Intervention to Improve Substance Use Disorder Treatment Outcomes Among Rural and Highly Rural Veterans
|
N/A | |
| Completed |
NCT01237366 -
Study Targeting Affect Regulation
|
Phase 1/Phase 2 | |
| Terminated |
NCT01356667 -
Drum-Assisted Therapy for Native Americans
|
N/A | |
| Completed |
NCT00708890 -
Twelve Step Based Self-help Groups for Substance Related Disorders
|
N/A | |
| Active, not recruiting |
NCT04048850 -
Zepatier in Patients With Substance Use
|
||
| Recruiting |
NCT05976646 -
Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion
|
Phase 1/Phase 2 |