Neuroimaging and CBD for Opiod Use Disorder

Substance-Related Disorders Clinical Trial

Official title:

Neuroimaging and CBD for Opiod Use Disorder

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04567784
• Other study ID #: HS#: 19-00293
• Status: Recruiting
• Phase: Phase 2
• Start date: November 12, 2020
• Est. completion date: November 12, 2025

Study information

• Verified date: September 2023
• Source: Hurd,Yasmin, Ph.D.
• Contact: Ashanta Carter
• Phone: 212-585-4653
• Email: ashanta.carter[@]mssm.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators propose an imaging study to investigate the neurobiological effects of CBD (vs placebo) in participants with opioid use disorder who are maintained on methadone. The purpose of the study is to determine the neural circuits and transmitters associated with the effects of CBD on to reduce craving and anxiety. The neuroimaging will be conducted in participants immediately following their first administration of CBD (800mg or placebo) and one week after the last administration (3 daily doses). This CBD administration protocol was shown in previous studies by the investigators to reduce craving and anxiety in abstinent heroin users.

Description:

This study will first use multimodal imaging in individuals with opiod use disorder who are maintained on methadone to determine the neural circuits associated with the effects of CBD on craving and anxiety. Secondly, the investigators will conduct 1H MRS to characterize in-vivo neurochemical levels associated with CBD administration. Altogether, the data obtained will fill critical gaps of knowledge important in the development of a potential non-opioid medication for treating opioid use disorder. CBD has been shown to be safe in association with opioid use and not to have severe side effects. The oral CBD solution (Epidiolex) to be used in the current study is approved by the FDA for the treatment of seizures associated with two rare and severe forms of epilepsy, Lennox-Gastaut syndrome and Dravet syndrome, in patients 2 years of age and older. Our study will investigate the neurobiological effects of CBD which is critical for its development as a potential treatment for opioid use disorder in the future. Study participation duration will last 2 weeks and will include multimodal imaging techniques to examine neural connectivity, neural activity and glutamate (and other neurometabolites) levels in relation to the impact on cue-induced responses in OUD subjects. The imagining sessions will include CBD/placebo administration; Magnetic Resonance Imaging (MRI) during task and resting-state functional MRI (rs-fMRI) and Magnetic Resonance spectroscopy (MRS); and questionnaires measuring craving, anxiety, depression, elements of cognitive function, and psychiatric history. Screening: Study candidates will be recruited through flyers, ads and referrals from AIMS clinics. At the initial phone contact candidates will be screened for exclusion criteria and provided study information and, if they remain interested and no exclusion criteria are encountered, invited for in-person screening. Candidates will then undergo the informed consent procedure, be fully screened for eligibility and complete baseline assessments. Randomization: Participants will be randomly assigned to either CBD or Placebo condition.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 160
• Est. completion date: November 12, 2025
• Est. primary completion date: November 12, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. Individuals between 18 and 65 years old.

2. Current methadone maintenance in an opioid treatment program with a dose of =/>40mg for at least 14 days prior to participation and prescribed take-home methadone medication.

3. Current opioid use disorder (OUD) or OUD in remission while on maintenance therapy with opioid agonist therapy (OAT), as determined by DSM-5 with the M.I.N.I. interview (Mini-International Neuropsychiatric Interview).

4. Urinary toxicology positive for methadone.

Exclusion Criteria:

1. Non-English speaking.

2. Court mandate to treatment.

3. Participation in another pharmacotherapeutic trial in the past 3 months.

4. Poor physical health (as determined by medical screen) that would make study participation unsafe, or would prevent adherence to study procedures, including a history of cardiac disease, arrhythmias, head trauma, and seizures.

5. Psychiatric conditions under DSM-5 (examined with the MINI) that would make study participation unsafe or which would prevent adherence to study procedure; examples include: suicidal or homicidal ideation requiring immediate attention, or inadequately-treated mental health disorder (e.g. active psychosis or uncontrolled bipolar disorder).

6. History of impaired renal function or elevated liver enzymes >2x the normal at prescreening.

7. QTc Frederica >500ms.

8. Current pregnancy [determined by positive urine test] or breastfeeding.

9. Not using an appropriate method of contraception such as hormonal contraception (oral hormonal contraceptives, Depo-Provera, Nuva-Ring), intrauterine device (IUD), sterilization, or double barrier method (combination of any two barrier methods used simultaneously, i.e. condom, spermicide, diaphragm).

10. Medical or psychiatric contraindications for MRI (metal implants, stents, etc).

11. Medical or psychiatric contraindications for CBD administration (e.g., history of hypersensitivity to cannabinoids).

12. Current diagnosis of a moderate or severe substance use disorder (except for opioids and nicotine) in the past 3 months, based on DSM-5.

13. Acute drug intoxication as determined by clinician assessment.

14. Acute opioids withdrawal symptoms (observational and determined by the Clinical Opiate Withdrawal Scale (COWS). A Score of =#5 will be considered a positive result for withdrawal symptoms and/or by clinical judgment.

15. Breathalyzer/Alcohol salivary/urine strips positive for alcohol.

Related Conditions & MeSH terms

• Heroin Abuse
• Heroin Dependence
• Opioid Use Disorder
• Opioid-Related Disorders
• Substance-Related Disorders

Intervention

Drug:
• Cannabidiol (CBD)
Subjects in Arm CBD 800 mg will receive 800mg of Cannabidiol in each of the three test sessions
• Placebo
Subjects will receive a harmless, inactive solution to compare and validate the results of the other arms of the study

Locations

Country	Name	City	State
United States	Icahn School of Medicine at Mount Sinai	New York	New York

Sponsors (2)

Lead Sponsor	Collaborator
Hurd,Yasmin, Ph.D.	Jazz Pharmaceuticals

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Adverse Events as assessed by the SAFTEE	The Systematic Assessment for Treatment of Emergent Events (SAFTEE) is a structured instrument for collecting adverse drug effects.	post-intervention, approximately 1 week
Primary	CBD effects on in vivo glutamatergic levels within mesocorticolimbic brain regions	Effects of CBD on in-vivo glutamatergic levels within mesocorticolimbic brain regions using Proton-Magnetic resonance spectroscopy.	2 MRI Scans (duration 30 mins)
Primary	Change in fMRI BOLD signal during cue reactivity	Change in fMRI blood-oxygen-level dependent (BOLD) signal acquired during the cue reactivity task at the 2nd MRI conducted 1 week after intervention as compared to the 1st MRI.	2 MRI Scans (duration 15 mins)
Primary	Change in fMRI BOLD signal acquired during resting-state functional connectivity	Change in fMRI blood-oxygen-level dependent (BOLD) signal acquired during resting-state at the 2nd MRI conducted 1 week after intervention as compared to the 1st MRI.	2 MRI Scans (duration 10 mins)
Secondary	Change in cue-induced drug craving on the VAS	Change in cue-induced drug craving will be measured through the Visual Analogue Scale for craving, 0 (not at all) to 10 (extremely) approximately 10 days after enrollment.	1 week post-intervention
Secondary	Change in cue-induced anxiety on the VAS	Change in cue-induced anxiety will be measured through the Visual Analogue Scale for anxiety, 0 (not at all) to 10 (extremely) approximately 10 days after enrollment.	1 week post-intervention
Secondary	Systolic and diastolic blood pressure (in mmHg)	Change in blood pressure.	2 hours post-dose
Secondary	Heart rate (in beats/min)	Change in heart rate.	2 hours post-dose