Substance-Related Disorders Clinical Trial
— (DARC)Official title:
Alcohol, Behavior, and Brain Imaging
Verified date | February 2022 |
Source | University of Chicago |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
To evaluate the relationship of extraversion to both the acute subjective and behavioral effects of alcohol, and the neural reactivity to the anticipation of reward.
Status | Completed |
Enrollment | 80 |
Est. completion date | May 30, 2019 |
Est. primary completion date | May 30, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 21 Years to 29 Years |
Eligibility | Inclusion Criteria: - 21-29 years old - 7-30 alcoholic drinks per week (as reported on PHQ or TLFB) - At least one binge episode (4 for females/5 for males) per month - No 'flushing' reaction to alcohol - Females must be on birth control or in the beginning of follicular phase (1-14 days after start of menstruation) - BMI 19-26 - High school education or greater, fluent in English - No night shift work - No current or past year Axis I psychiatric disorder including drug/alcohol dependence - No current psychopharmacological treatment - No lifetime ADHD or prescription for ADHD medication - No abnormal EKG, cardiovascular illness, high blood pressure - No medical condition or pharmacological treatment for which alcohol is contraindicated - Not pregnant, lactating, or planning to become pregnant - Smoke <6 cigarettes per day - No previous participation in studies that have used the Stop Task (except IDAC) o Previous Stop Task studies: GOI, CAP, STEM, JAM, MACI, PAC, CAM |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University of Chicago |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Stop Signal Task (SST) | The Stop-Signal Task (SST) is a task requiring inhibition of a prepotent motor response. The SST requires participants to respond to a target stimulus as quickly and accurately as possible by pressing a button, but also to withhold their response when they hear an auditory signal. Thus, this task involves a competition between activating and inhibiting processes. The primary outcome variable is change in the stop signal reaction time (SSRT) for the task administered seconds to minutes before and seconds to minutes after stimulation. The theoretical minimum is zero seconds and there is no theoretical maximum. Higher SSRT scores reflect greater impulsivity. | Within an hour post-stimulation condition |
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