Substance-Related Disorders Clinical Trial
Official title:
Effects of Bupropion on Marijuana Withdrawal Symptoms
A definable and significant withdrawal syndrome occurs upon cessation of chronic, heavy marijuana use. Bupropion (Zyban) is a medication currently used to treat withdrawal symptoms associated with tobacco use. The purpose of this study is to determine if bupropion will help individuals stop using marijuana.
Status | Completed |
Enrollment | 30 |
Est. completion date | May 2006 |
Est. primary completion date | May 2006 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - Current marijuana use and dependence - Marijuana use of at least 5 times in the past 7 days or more than 25 times per month for the 3 years prior to enrollment - Unsuccessful in a previous attempt to quit marijuana Exclusion Criteria: - Axis I disorder - Any drug abuse or dependence other than marijuana - Currently taking antipsychotic or antidepressant medication - Heavy alcohol drinker (more than 20 drinks per week) - Current nicotine dependence - History of a seizure disorder - Current or prior eating disorder (e.g., bulimia or anorexia nervosa) - Heavy caffeine use (more than 300 mg per day) - Life threatening or unstable medical illness - Pregnant |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | McLean Hospital, Dept. of Psychiatry | Belmont | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
National Institute on Drug Abuse (NIDA) |
United States,
Penetar DM, Looby AR, Ryan ET, Maywalt MA, Lukas SE. Bupropion reduces some of the symptoms of marihuana withdrawal in chronic marihuana users: a pilot study. Subst Abuse. 2012;6:63-71. doi: 10.4137/SART.S9706. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Withdrawal severity | on a daily basis for 14 days | No |
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