Substance-Related Disorders Clinical Trial
Official title:
Translating Depression Guidelines Into Substance Abuse Treatment
Verified date | February 2007 |
Source | VA Office of Research and Development |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Interventional |
Comorbid depression has been consistently linked to worse outcomes for patients in substance abuse treatment programs. Practice guidelines recommend pharmacotherapy for comorbid depression if symptoms persist after a 4-week "wash-out" period for detoxification (e.g., Veterans Health Administration; American Psychiatric Association). Medications may be considered earlier if a patient has current symptoms and a history of major depressive disorder (MDD) during periods of sobriety. Current efficacy data suggest that antidepressant medication can improve both depression and substance use outcomes among comorbid patients Guideline-concordant use of antidepressant medication for persons with comorbid substance use and depressive disorders, however, is not routine in many VA substance abuse treatment settings.
Status | Completed |
Enrollment | 300 |
Est. completion date | October 2006 |
Est. primary completion date | October 2006 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: Programs: VA's offering residential or intensive outpatient treatment for substance-related disorders in VISN 16 Patients: Veterans in residential or intensive outpatient treatment for substance-related disorders; positive screen for non-substance-induced depressive disorder Exclusion Criteria: |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label
Country | Name | City | State |
---|---|---|---|
United States | VA Gulf Coast Veterans Health Care System | Biloxi | Mississippi |
United States | G.V. (Sonny) Montgomery VA Medical Center, Jackson, MS | Jackson | Mississippi |
United States | Southeast Louisiana Veterans Health Care System, New Orleans, LA | New Orleans | Louisiana |
United States | Central Arkansas Veterans Healthcare System Eugene J. Towbin Healthcare Center, Little Rock, AR | No. Little Rock | Arkansas |
United States | Oklahoma City, OK | Oklahoma City | Oklahoma |
Lead Sponsor | Collaborator |
---|---|
VA Office of Research and Development |
United States,
Curran GM, Kirchner JE, Worley M, Rookey C, Booth BM. Depressive symptomatology and early attrition from intensive outpatient substance use treatment. J Behav Health Serv Res. 2002 May;29(2):138-43. — View Citation
Curran GM, Mukherjee S, Allee E, Owen RR. A process for developing an implementation intervention: QUERI Series. Implement Sci. 2008 Mar 19;3:17. doi: 10.1186/1748-5908-3-17. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Program: extent, quality of adoption of protocolPatient: scores on-depression, substance use, and functioning scales | No | ||
Secondary | Programs: Staff satisfaction with protocol/intervention Patients: medication adherence | No |
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