Buprenorphine/Naloxone for Opiate-Dependence Treatment - 1

Substance-Related Disorders Clinical Trial

Official title:

CS1008A Efficacy/Safety Trial of Buprenorphine/Naloxone

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00015028
• Other study ID #: NIDA-5-0012-1
• Secondary ID: Y01-5-0012-1
• Status: Completed
• Phase: Phase 2
• First received: April 18, 2001
• Last updated: January 13, 2017
• Start date: November 1996
• Est. completion date: January 1997

Study information

• Verified date: November 1996
• Source: National Institute on Drug Abuse (NIDA)
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the efficacy and safety of a buprenorphine/naloxone sublingual tablet formulation as an office-based therapy for opiate-dependence treatment. The developmental objective for this combination product is an expansion of therapeutic options for the treatment of opiate dependence.

Description:

This multicenter pivotal clinical trial was comprised of two phases. The first phase, which was four weeks in length, was double-blind placebo controlled and was primarily used to evaluate the efficacy of buprenorphine/naloxone. The second phase, lasting 48 weeks, was primarily conducted to determine the safety of buprenorphine/naloxone.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Est. completion date: January 1997
• Est. primary completion date: December 1996
• Accepts healthy volunteers: No
• Gender: All
• Age group: 23 Years to 59 Years

Eligibility

Inclusion Criteria:

1. DSM-IV (Diagnostic and Statistical Manual of the American Psychiatric Association) diagnosis of current opiate dependence.

2. Individuals seeking opiate-substitution pharmacotherapy for opiate dependence.

3. Males and non-pregnant, non-nursing females, 18 to 59 years of age (inclusive).

4. Individuals able to give informed consent and willing to comply with all study procedures (e.g., providing of urine samples under observation, completing questionnaires).

Exclusion Criteria:

1. Any acute or chronic medical condition that would make participation in the study medically hazardous (e.g., acute hepatitis, unstable cardiovascular, hepatic, or renal disease, unstable diabetes, symptomatic AIDS; not HIV-seropositivity alone).

2. Aspartate or alanine aminotransferase (AST, ALT) levels greater than three times the upper limit of normal.

3. Individuals currently taking systemic anti-retroviral or anti-fungal therapy.

4. Current dependence (by DSM-IV criteria) on any psychoactive substance other than opiates, caffeine, or nicotine.

5. Current, primary, Axis I psychiatric diagnosis other than opiate, caffeine, or nicotine dependence.

6. Females of childbearing potential who do not agree to use a medically acceptable method of birth control. Acceptable methods include

1. oral contraceptive,

2. barrier (diaphragm or condom) - a spermicide is not required due to the possibility of local irritation and allergic type reactions, but are recommended for use,

3. levonorgestrel implant,

4. intrauterine progesterone contraceptive system,

5. medroxyprogesterone acetate contraceptive injection, or

6. complete abstinence.

7. Enrollment in an opiate-substitution (i.e., methadone, levo-alpha-acetylmethadol) treatment program within 45 days of enrolling in the present study.

8. Individuals having taken (licitly or illicitly) LAAM, methadone, or naltrexone within days of enrolling in the present study.

9. Individuals having taken buprenorphine, other than as an analgesic, within 365 days of enrolling in the present study.

10. Participation in an investigational drug or device study within 45 days of enrolling in the present study.

11. Anyone, who in the opinion of site principal investigator, would not be expected to complete the first phase of the study protocol (e.g., due to pending incarceration or probable relocation from the clinic area).

Related Conditions & MeSH terms

• Disease
• Opioid-Related Disorders
• Substance-Related Disorders

Intervention

Drug:
• Buprenorphine/naloxone

Locations

Country	Name	City	State
United States	Cincinnati MDRU	Cincinnati	Ohio

Sponsors (2)

Lead Sponsor	Collaborator
National Institute on Drug Abuse (NIDA)	Cincinnati MDRU

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Craving
Primary	Drug use
Primary	HIV risk behaviors
Primary	Adverse events
Primary	Medical evaluation