Role of Instructions in Nitrous Oxide Effects and Choice - 10

Substance-Related Disorders Clinical Trial

Official title:

Role of Instructions in Nitrous Oxide Effects and Choice

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00000258
• Other study ID #: NIDA-08391-10
• Secondary ID: R01DA008391R01-0
• Status: Completed
• Phase: N/A
• First received: September 20, 1999
• Last updated: May 26, 2015
• Start date: April 1996
• Est. completion date: November 1997

Study information

• Verified date: May 2015
• Source: University of Chicago
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To evaluate the role of instructions in nitrous oxide subjective effects and choice.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: November 1997
• Est. primary completion date: November 1997
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 21 Years to 32 Years
• Eligibility: Please contact site for information.

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)

Related Conditions & MeSH terms

• Disease
• Opioid-Related Disorders
• Substance-Related Disorders

Intervention

Drug:
• Nitrous oxide 10% & placebo

• Nitrous oxide 20% & placebo

• Nitrous oxide 30% & placebo

• Nitrous oxide 40% and placebo

Locations

Country	Name	City	State
United States	University of Chicago, Anesthesia & Critical Care	Chicago	Illinois

Sponsors (2)

Lead Sponsor	Collaborator
University of Chicago	National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

References & Publications (1)

Zacny JP, Cho AM, Toledano AY, Galinkin J, Coalson DW, Klock PA, Klafta JM, Young CJ. Effects of information on the reinforcing, subjective, and psychomotor effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend. 1997 Nov 25;48(2):85-95. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Choice of nitrous oxide vs placebo	Subjects inhaled placebo and varying per centages of nitrous oxide in sampling pair, then chose for third inhalation. One group was told which of the gases they were inhaling during sampling and one group as well as the technician administering the inhalant was blinded. Psychomotor tests were done at each dose.	After 30 min inhalation of each	No