Substance-Related Disorders Clinical Trial
Official title:
Effects of Alcohol History on Effects of Nitrous Oxide
Verified date | May 2015 |
Source | University of Chicago |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Interventional |
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To determine effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers.
Status | Completed |
Enrollment | 19 |
Est. completion date | April 1997 |
Est. primary completion date | April 1997 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 21 Years to 37 Years |
Eligibility | Please contact site for information. |
Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)
Country | Name | City | State |
---|---|---|---|
United States | University of Chicago, Anesthesia & Critical Care | Chicago | Illinois |
Lead Sponsor | Collaborator |
---|---|
University of Chicago | National Institute on Drug Abuse (NIDA) |
United States,
Cho AM, Coalson DW, Klock PA, Klafta JM, Marks S, Toledano AY, Apfelbaum JL, Zacny JP. The effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend. 1997 Apr 14;45(1-2):63-70. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Choice of nitrous oxide vs placebo | Two subject groups (light drinkers vs moderate drinkers) were asked to inhale a given conc of N2O and inhale a placebo, then choose for a third inhalation. The subject & the technician administering the inhalant were blinded. Testing was done at each dose. | After 30 min inhalation each of N2O and placebo | No |
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