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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00000257
Other study ID # NIDA-08391-9
Secondary ID R01DA008391R01-0
Status Completed
Phase N/A
First received September 20, 1999
Last updated May 26, 2015
Start date September 1995
Est. completion date April 1997

Study information

Verified date May 2015
Source University of Chicago
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Interventional

Clinical Trial Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To determine effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers.


Recruitment information / eligibility

Status Completed
Enrollment 19
Est. completion date April 1997
Est. primary completion date April 1997
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 21 Years to 37 Years
Eligibility Please contact site for information.

Study Design

Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)


Intervention

Drug:
0% N2O and 10% N2O

0% N2O and 20% N2O

0% N2O and 30% N2O

0% N2O and 40% N2O


Locations

Country Name City State
United States University of Chicago, Anesthesia & Critical Care Chicago Illinois

Sponsors (2)

Lead Sponsor Collaborator
University of Chicago National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

References & Publications (1)

Cho AM, Coalson DW, Klock PA, Klafta JM, Marks S, Toledano AY, Apfelbaum JL, Zacny JP. The effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend. 1997 Apr 14;45(1-2):63-70. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Choice of nitrous oxide vs placebo Two subject groups (light drinkers vs moderate drinkers) were asked to inhale a given conc of N2O and inhale a placebo, then choose for a third inhalation. The subject & the technician administering the inhalant were blinded. Testing was done at each dose. After 30 min inhalation each of N2O and placebo No
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