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NCT00000255 Clinical Trial

Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7

Substance-Related Disorders Clinical Trial

Official title:
Differential Acute Tolerance Development to Effects of Nitrous Oxide

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00000255
Other study ID # NIDA-08391-7
Secondary ID R01DA008391R01-0
Status Completed
Phase Phase 2
First received September 20, 1999
Last updated May 26, 2015
Start date April 1995
Est. completion date May 1996

Study information
Verified date May 2015
Source University of Chicago
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Interventional

Clinical Trial Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine differential acute tolerance development to effects of nitrous oxide in humans.

Recruitment information / eligibility
Status Completed
Enrollment 10
Est. completion date May 1996
Est. primary completion date May 1996
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 21 Years to 37 Years
Eligibility Please contact site for information.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Drug:
• Nitrous oxide

Locations
Country Name City State
United States University of Chicago, Anesthesia & Critical Care Chicago Illinois

Sponsors (2)
Lead Sponsor Collaborator
University of Chicago National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

References & Publications (1)

Zacny JP, Cho AM, Coalson DW, Rupani G, Young CJ, Klafta JM, Klock PA, Apfelbaum JL. Differential acute tolerance development to effects of nitrous oxide in humans. Neurosci Lett. 1996 May 10;209(2):73-6. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Pain intensity, pain bothersomeness Subjects will inhale varying conc of nitrous oxide for 120 min with cold immersion of forearm at 25, 70, and 115 min and 40 min after inhalation. Pain intensity and bothersomeness will be assessed at each immersion. 25, 70, & 115 min of inhalation and 40 min post No
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