Effects of Nitrous Oxide: A Dose-Response Analysis - 5

Substance-Related Disorders Clinical Trial

Official title:

Effects of Nitrous Oxide: A Dose-Response Analysis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00000253
• Other study ID #: NIDA-08391-5
• Secondary ID: R01DA008391R01-0
• Status: Completed
• Phase: N/A
• First received: September 20, 1999
• Last updated: May 26, 2015
• Start date: November 1994
• Est. completion date: March 1996

Study information

• Verified date: May 2015
• Source: University of Chicago
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the subjective, psychomotor, and reinforcing effects of nitrous oxide in healthy volunteers. This is a dose-response analysis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: March 1996
• Est. primary completion date: March 1996
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 21 Years to 37 Years
• Eligibility: Please contact site for information.

Study Design

Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)

Related Conditions & MeSH terms

• Disease
• Opioid-Related Disorders
• Substance-Related Disorders

Intervention

Drug:
• 10% N2O

• 20% N2O

• 30% N2O

• 40% N2O

Locations

Country	Name	City	State
United States	University of Chicago, Anesthesia & Critical Care	Chicago	Illinois

Sponsors (2)

Lead Sponsor	Collaborator
University of Chicago	National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

References & Publications (1)

Zacny JP, Lichtor JL, Coalson DW, Alessi R, Goldsher G, Young CJ, Apfelbaum JL, Conley KM. Examining the subjective, psychomotor and reinforcing effects of nitrous oxide in healthy volunteers: a dose-response analysis. Behav Pharmacol. 1996 Mar;7(2):194-199. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Choice of N2O vs. placebo	Subjects underwent 4 sessions consisting of 2 sample tests (inhaling placebo and inhaling varying doses of N2O), then choosing which inhalant they wanted for a choice test. The subject & the technician administering the inhalant were blinded. During each intervention and each session, subjects underwent psychomotor testing.	After each pair of sample tests	No