Clinical Trials Logo
  1. Home
  2. Substance-Related Disorders
  3. NCT00000249
  4. Details
NCT00000249 Clinical Trial

Effects of Subanesthetic Concentrations of Nitrous Oxide - 1

Substance-Related Disorders Clinical Trial

Official title:
Effects of Subanesthetic Concentrations of Nitrous Oxide

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00000249
Other study ID # NIDA-08391-1
Secondary ID R01DA008391R01-0
Status Completed
Phase Phase 2
First received September 20, 1999
Last updated May 26, 2015
Start date September 1993
Est. completion date June 1995

Study information
Verified date May 2015
Source University of Chicago
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Interventional

Clinical Trial Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans.

Recruitment information / eligibility
Status Completed
Enrollment 10
Est. completion date June 1995
Est. primary completion date June 1995
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 21 Years to 37 Years
Eligibility Please contact site for information.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Drug:
• 20% N2O
20% inhaled N2O
• 30% N2O
30% inhaled N2O
• 40% N2O
40% inhaled N2O

Locations
Country Name City State
United States University of Chicago, Anesthesia & Critical Care Chicago Illinois

Sponsors (2)
Lead Sponsor Collaborator
University of Chicago National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

References & Publications (1)

Pharmocol Biochem and Behavior 1995, 51( 2): 323-329

Outcome
Type Measure Description Time frame Safety issue
Primary Pain intensity Subjects immersed non-dominant arm for 3 minutes twice in 2-3 degree C water while inhaling 0 (placebo), 20, 30, or 40% N2O for a total of 40 minutes during cold test at 10 min & 30 min of inhalation No
See also
  Status Clinical Trial Phase
Recruiting NCT05054738 - CRP and S&A for Inpatient Veterans N/A
Recruiting NCT04157062 - An Open-Label Trial of Repetitive Transcranial Magnetic Stimulation for Opioid Use Disorder N/A
Completed NCT02233738 - Group Motivational Interviewing (GMI) For Homeless Veterans In VA Services N/A
Enrolling by invitation NCT06084221 - Fatal Overdose Review Teams - Research to Enhance Surveillance Systems N/A
Completed NCT02907944 - Working With HIV Clinics to Adopt Addiction Treatments Using Implementation Facilitation N/A
Completed NCT02829970 - Helping College Students With ADHD Lead Healthier Lifestyles N/A
Completed NCT02570360 - Exercise and Treatment-as-usual in Substance Use Treatment Outcomes N/A
Completed NCT02125539 - Field Trial of a Relapse Prevention Program for Adolescents Receiving Substance Use Treatment Phase 2
Completed NCT02715557 - Arise: An Online Relapse Prevention Tool for Adolescent Substance Abusers N/A
Completed NCT02945371 - Tailored Inhibitory Control Training to Reverse EA-linked Deficits in Mid-life N/A
Completed NCT02388243 - The Computer-based Drug and Alcohol Training Assessment in Kenya N/A
Completed NCT02218970 - The Effect of Muscular Strength Training in Patients With Drug Addiction N/A
Completed NCT01633138 - Performance-based Reinforcement to Enhance Cognitive Remediation Therapy N/A
Completed NCT01591239 - Home-Based Program to Help Parents of Drug Abusing Adolescents N/A
Active, not recruiting NCT01539525 - Screening to Augment Referral to Treatment- Project START Phase 2
Withdrawn NCT01224002 - A Comparative Feasibility Study to Assess the Prevalence and Severity of Dental Caries in Incarcerated People Who Abuse Methamphetamine N/A
Withdrawn NCT00891631 - Primary Care iSBIRT to Reduce Serious Teen Health Risks Phase 1/Phase 2
Completed NCT01365247 - Concurrent Treatment for Substance Dependent Individuals With Post-Traumatic Stress Disorder (PTSD) N/A
Completed NCT00970372 - Dual-Diagnosis and Compulsory Treatment N/A
Completed NCT00419029 - Motivational Interviewing to Engage Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans in Mental Health Treatment N/A