miRNA Profile in Aneurysmal Subarachnoid Haemorrhage

Subarachnoid Hemorrhage Clinical Trial

— miRNA  

Official title:

Circulating and CSF miRNA Profile in Patients With Acute Aneurysmal Subarachnoid Haemorrhage

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03344744
• Other study ID #: miSAH003
• Status: Completed
• Start date: November 30, 2017
• Est. completion date: August 31, 2023

Study information

• Verified date: September 2023
• Source: Chinese University of Hong Kong
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The investigators aim to investigate and understand the circulating miRNA profiles after acute aneurysmal subarachnoid haemorrhage and underlying pathological significance.

Description:

1. The investigators aim to investigate the miRNA classifier for delayed cerebral infarction after aneurysmal subarachnoid haemorrhage;

2. The investigators aim to investigate the corresponding circulating and CSF miRNA profiles.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: August 31, 2023
• Est. primary completion date: August 31, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 21 Years to 75 Years

Eligibility

Inclusion Criteria:

Aneurysmal subarachnoid hemorrhage patients within the first 72 hours or Healthy volunteers

Exclusion Criteria:

Previous neurological diseases such as stroke or dementia

Related Conditions & MeSH terms

• Hemorrhage
• Subarachnoid Hemorrhage

Locations

Country	Name	City	State
China	Department of Surgery, The Chinese University of Hong Kong	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
Chinese University of Hong Kong

Country where clinical trial is conducted

China, 

References & Publications (3)

Lu G, Wong MS, Xiong MZQ, Leung CK, Su XW, Zhou JY, Poon WS, Zheng VZY, Chan WY, Wong GKC. Circulating MicroRNAs in Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage. J Am Heart Assoc. 2017 Apr 25;6(4):e005363. doi: 10.1161/JAHA.116.005363. — View Citation

Su XW, Chan AH, Lu G, Lin M, Sze J, Zhou JY, Poon WS, Liu Q, Zheng VZ, Wong GK. Circulating microRNA 132-3p and 324-3p Profiles in Patients after Acute Aneurysmal Subarachnoid Hemorrhage. PLoS One. 2015 Dec 16;10(12):e0144724. doi: 10.1371/journal.pone.0144724. eCollection 2015. — View Citation

Wong GK, Lam S, Ngai K, Wong A, Mok V, Poon WS; Cognitive Dysfunction after Aneurysmal Subarachnoid Haemorrhage Investigators. Evaluation of cognitive impairment by the Montreal cognitive assessment in patients with aneurysmal subarachnoid haemorrhage: prevalence, risk factors and correlations with 3 month outcomes. J Neurol Neurosurg Psychiatry. 2012 Nov;83(11):1112-7. doi: 10.1136/jnnp-2012-302217. Epub 2012 Jul 31. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Circulating micro RNA concentrations	Serum micro RNA concentrations	Day 3
Secondary	Circulating micro RNA change	Changes of serum micro RNA concentrations between days 1,2,3,7	Days 1,2,3,7
Secondary	Cerebrospinal fluid micro RNA concentrations	Cerebrospinal fluid micro RNA concentrations	Day 1,2,3,7
Secondary	Cerebrospinal fluid micro RNA change	Changes of cerebrospinal fluid micro RNA concentrations between days 1,2,3,7	Days 1,2,3,7