Subarachnoid Hemorrhage Clinical Trial
Official title:
The Pathogenesis of Terson Syndrome and the Role of CSF Tau / Amyloid-ß 40 and 42 in Patients With Aneurysmatic Subarachnoid Hemorrhage
Prospective clinical study to investigate the pathogenesis of Terson syndrome and the
prognostic value of the CSF-biomarkers tau-protein and amyloid-β 40 and 42 in patients with
aneurysmatic subarachnoid hemorrhage. Our two hypotheses are as follows:
1. The incidence of Terson syndrome correlates with the initial intracranial opening
pressure (measured with extra ventricular drain)
2. The CSF-biomarkers correlate with the outcome assessed at discharge, 3-, 6- and
12-months postictally using Glasgow-Outcome-Scale-Extended (GOSE) and Euro-Qol-5 as
well as with complications related to aneurysmatic subarachnoid hemorrhage such as
cerebral vasospasm, delayed cerebral ischemia and re-bleed.
In this prospective clinical study the pathogenesis of Terson syndrome and the prognostic
value of the CSF-biomarkers tau-proteine and amyloid-β 40 and 42 in patients with
aneurysmatic subarachnoidal hemorrhage are investigated. Intracranial opening pressure will
be measured in patients requiring CSF-diversion for acute hydrocephalus and correlated with
the incidence of Terson syndrome tested by an opthalmologic exam (group A: Terson syndrome
positive, group B: Terson syndrome negative). CSF samples from external ventricular
drainages are obtained at day 0, 2 and 6 and concentration of tau-protein and amyloid-β 40
and 42 are determined and correlated to secondary outcome measures such as delayed cerebral
ischemia, clinical vasospasm, re-bleed, necessity for surgical intervention secondary to
raised intracranial pressure or CSF-diversion. Outcome in terms of
Glasgow-Outcome-Scale-Extended and Euro-Qol-5 will be assessed at 3, 6 and 12 months.
CSF from patients undergoing diagnostic or therapeutic tapping of their internal ventricles
for normal pressure hydrocephalus or shunt diagnostics serve as a reference for
CSF-biomarkers concentration in healthy individuals.
;
Observational Model: Cohort, Time Perspective: Prospective
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT06043167 -
Clinimetric Application of FOUR Scale as in Treatment and Rehabilitation of Patients With Acute Cerebral Injury
|
||
Recruiting |
NCT04189471 -
Recovery After Cerebral Hemorrhage
|
||
Completed |
NCT03281590 -
Stroke and Cerebrovascular Diseases Registry
|
||
Completed |
NCT05131295 -
Dapsone Use in Patients With Aneurysmal Subarachnoid Hemorrhage.
|
Phase 3 | |
Recruiting |
NCT02962349 -
TRansfusion Strategies in Acute Brain INjured Patients
|
N/A | |
Completed |
NCT02872857 -
Subarachnoid Hemorrhage Recovery And Galantamine
|
Phase 1/Phase 2 | |
Terminated |
NCT02216513 -
Deferoxamine to Prevent Delayed Cerebral Ischemia After Subarachnoid Hemorrhage
|
Phase 0 | |
Completed |
NCT03164434 -
Influence of Drainage on EVD ICP-signal
|
||
Not yet recruiting |
NCT00905931 -
Lycopene Following Aneurysmal Subarachnoid Haemorrhage
|
Phase 2 | |
Completed |
NCT01077206 -
High-dose Simvastatin for Aneurysmal Subarachnoid Haemorrhage
|
Phase 2/Phase 3 | |
Completed |
NCT02389634 -
Identification of Novel Molecular Markers for Vasospasm
|
||
Completed |
NCT01261091 -
Early Tracheostomy in Ventilated Stroke Patients
|
N/A | |
Completed |
NCT00962546 -
Computed Tomographic (CT) Perfusion and CT Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage
|
N/A | |
Completed |
NCT00507104 -
Pituitary Functions After Traumatic Brain Injury (TBI) and/or Subarachnoid Hemorrhage (SAH)
|
||
Completed |
NCT00071565 -
Familial Intracranial Aneurysm Study II
|
N/A | |
Recruiting |
NCT05113381 -
The Purpose of This Study is to Determine Whether CerebroFlo™ EVD Catheter is Effective During the Treatment of IVH
|
N/A | |
Completed |
NCT04052646 -
Prehospital Deaths From Spontaneous Subarachnoid Haemorrhages
|
||
Recruiting |
NCT04548596 -
NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients
|
||
Recruiting |
NCT06033378 -
Blood Pressure Treatment in ICU Patients With Subarachniodal Haemorrhage.
|
N/A | |
Completed |
NCT04308577 -
Diet Induced Ketosis for Brain Injury - A Feasibility Study
|
N/A |