Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome

Status Completed

Clinical Trial Summary

The purpose of this research study is to gain a preliminary understanding of the safety of sirolimus in Sturge-Weber syndrome (SWS) and determine best outcomes to be used to assess the utility of sirolimus for the treatment of cognitive impairments related to Sturge-Weber syndrome.

Clinical Trial Description

Sirolimus will be administered as an adjunct to all current medications. The impact of sirolimus upon cognitive functioning in Sturge-Weber syndrome is the primary outcome measure. This outcome will be assessed using a panel of testing selected based upon extensive experience in testing cognitive function in adults and children with SWS at the Kennedy Krieger Sturge-Weber Center. Changes in a quantitative EEG before and after the trial, Sturge-Weber syndrome clinical neuroscore, port-wine birthmark score, and the impact of sirolimus upon seizures will be assessed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03047980
Study type	Interventional
Source	Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Contact
Status	Completed
Phase	Phase 2/Phase 3
Start date	January 2017
Completion date	October 27, 2020

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See also
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