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Clinical Trial Summary

The goal of this prospective cohort study is to investigate cardiac comorbidity in a random sample of approximately 1200 patients from a population of outpatients with rheumatoid arthritis and axial spondyloarthritis referred to collectively as inflammatory arthritis (IA). The main questions it aims to answer are: - Using conventional echocardiography, the investigators aim to determine the prevalence of overt and asymptomatic cardiac dysfunction in a large random sample of outpatients with IA. Cardiac dysfunction will be evaluated by echocardiography and cardiac biomarkers (NT-pro-BNP, hs-TNT and hs-CRP). - In patients without known heart disease: Using 2, 5 and 10 year follow-up, the investigators aim to examine if advanced echocardiography can be used to detect early signs of heart disease by investigating the clinical significance of adding deformation measures - alone and in combination with selected biomarkers - to conventional risk factors in the cardiac risk assessment of patients with IA Participants will undergo an echocardiographic examination in combination with a general health assessment including obtainment of cardiac biomarkers and a electrocardiogram. Using advanced echocardiography - Tissue Doppler Imaging, 2- dimensional speckle tracking echocardiography, 3D-echocardiography and 3-dimensional speckle tracking echocardiography - the investigators also aim to compare myocardial deformation parameters of patients with IA to a gender and age matched control group without IA from the Copenhagen City Heart Study.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Arthritis
  • Axial Spondyloarthritis
  • Cardiac Disease
  • Coronary Artery Disease
  • Heart Diseases
  • Heart Failure
  • Heart Failure, Diastolic
  • Heart Failure, Systolic
  • Heart Valve Diseases
  • Inflammatory Arthritis
  • Ischemic Heart Disease
  • Left Ventricular Systolic Dysfunction
  • Myocardial Dysfunction
  • Myocardial Infarction
  • Myocardial Ischemia
  • Rheumatoid Arthritis
  • Spondylarthritis
  • Spondylitis
  • Spondylitis, Ankylosing
  • Spondyloarthritis
  • Stroke
  • Systolic Murmurs
  • Valvular Heart Disease
  • Ventricular Dysfunction, Left

NCT number NCT05647577
Study type Observational [Patient Registry]
Source University Hospital, Gentofte, Copenhagen
Contact
Status Active, not recruiting
Phase
Start date January 1, 2021
Completion date March 1, 2033

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