Study of Botulinum Toxin and Recovery of Hand Function After Stroke

Stroke With Hemiparesis Clinical Trial

Official title: Botulinum Toxin Type A Therapy as a Plasticity Inducing Agent for Recovery of Hand Function After Stroke

Status Completed

Clinical Trial Summary

The purpose of this study is to determine whether injections of botulinum toxin (commonly known as BOTOX®) into the affected hand of Stroke patients, while targeting the muscles controlling the hand, will lead to improved use of the hand when compared to injections of placebo (a substance that looks similar to the study drug but contains no active study medication).

Clinical Trial Description

Hemiparesis is the most common motor impairment after stroke that frequently leads to persistent deficits in hand function. This study investigates whether the application of botulinum toxin to a set of synergistically-acting hand muscles, in conjunction with task-specific therapy, will lead to reorganization and improved motor function in the stroke-involved hand. The investigators will use objective psychophysical measures of hand function and hand function rating scales to investigate if Botox in conjunction with task-specific therapy will lead to:

• improved motor execution,

• improved motor planning during a psychophysical two-finger grasping and lifting task with varying object weight, and

• increased hand function as assessed by the time taken to complete fine motor tasks. ;

Related Conditions & MeSH terms

• Paresis
• Stroke
• Stroke With Hemiparesis

• NCT number: NCT01422161
• Study type: Interventional
• Source: NYU Langone Health
• Status: Completed
• Phase: Phase 3
• Start date: April 2010
• Completion date: October 2015