Clinical Trials Logo
  1. Home
  2. Stroke Rehabilitation
  3. NCT05505201

Effectiveness of Transcranial Magnetic Stimulation in Subacute Stroke Patients With Severe Upper Limb Paresis

Stroke Rehabilitation Clinical Trial

Official title:
Effectiveness of Add-on Inhibitory Repetitive Transcranial Magnetic Stimulation Over the Contralesional Primary Motor Cortex in Subacute Stroke Patients With Severe Upper Limb Motor Impairment

Clinical Trial Summary

There has been A-level evidence for the effectiveness of inhibitory rTMS of the contralesional M1 hand region in stroke patients in the acute stage. However, it has been reported to be ineffective in the chronic stage. In addition, it has been reported that the patient group benefiting from rTMS is mostly those with moderate to mild motor impairment. In contrast, a recent randomized controlled study has reported that ipsilesional excitatory rTMS or contra-lesional inhibitory rTMS may also have positive effects in stroke patients with severe upper limb motor impairment. The aim of this study is to investigate the effect of inhibitory repetitive transcranial magnetic stimulation applied to the contralesional primary motor cortex, by using the rTMS parameters specified in the current recommendation guide, on motor function, activities of daily living, and quality of life in subacute stroke patients with severe upper limb motor impairment.

Clinical Trial Description

The level of stroke-related upper limb motor impairment varies widely among individuals, from mild to severe. Because of this heterogeneity, rehabilitation interventions are tailored individually. In recent years, many studies have been published on the effectiveness of add-on non-invasive neuromodulation methods such as transcranial magnetic stimulation (TMS) or transcranial direct current stimulation in the treatment of stroke-related upper limb motor impairment. There has been A-level evidence for the effectiveness of inhibitory rTMS of the contralesional M1 hand region in stroke patients in the acute stage. However, it has been reported to be ineffective in the chronic stage. In addition, it has been reported that the patient group benefiting from rTMS is mostly those with moderate to mild motor impairment. It has been reported that contra-lesional hemisphere inactivation impairs paretic upper extremity performance in severely infarcted animals. In humans, contra-lesional hemisphere inactivation has been reported to slow down the reaction time. In contrast, a recent randomized controlled study has reported that ipsilesional excitatory rTMS or contralesional inhibitory rTMS may have positive effects in stroke patients with severe upper limb motor impairment. However, the literature on rTMS in post-stroke rehabilitation is highly heterogeneous in terms of frequency, session duration, location, patient characteristics, and outcome scales, and this ambiguity makes it difficult to adapt rTMS to the clinical practice. In this regard, future studies are needed to determine whether rTMS provides an additional benefit to traditional/task-specific rehabilitation approaches in stroke patients with severe upper limb paresis. The aim of this study is to investigate the effect of inhibitory repetitive transcranial magnetic stimulation applied to the contralesional primary motor cortex, by using the rTMS parameters specified in the current recommendation guide, on motor function, activities of daily living, and quality of life in subacute stroke patients with severe upper limb motor impairment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05505201
Study type Interventional
Source Izmir Katip Celebi University
Contact Ilker Sengül, M.D.
Phone 0905337333698
Email ilkrsngl@gmail.com
Status Recruiting
Phase N/A
Start date November 11, 2022
Completion date September 30, 2025
View Details
See also
  Status Clinical Trial Phase
Completed NCT03031977 - Visceral Mobilization and Functional Constipation in Stroke Survivors N/A
Not yet recruiting NCT04378946 - Error Augmentation Motor Learning Training Approach in Stroke Patients N/A
Recruiting NCT05690165 - Effects of Aerobic Exercise During the Early Rehabilitation After Ischemic Stroke N/A
Not yet recruiting NCT06053970 - Study Evaluating the Effect of Moving Virtual Scenes on Postural Balance in a Stroke Rehabilitation Setting N/A
Completed NCT03023150 - Ischemic Preconditioning as an Intervention to Improve Stroke Rehabilitation - Froedtert N/A
Terminated NCT04014270 - Self-modulated Functional Electrical Stimulation in Chronic Stroke Patients With Severe and Moderate Upper Limb Paresis N/A
Not yet recruiting NCT06128187 - The Effect of Dual Task Training on Upper Extremity Functions in Stroke Patients N/A
Completed NCT03773653 - Synergistic Bilateral Upper-Limb Stroke Rehabilitation Based on Robotic Priming Technique N/A
Recruiting NCT04800601 - Walking Ankle isoKinetic Exercise N/A
Recruiting NCT05993091 - Mirror Therapy and Augmented Reality in Stroke Rehabilitation N/A
Recruiting NCT04682223 - Telerehabilitation for Aphasia (TERRA) N/A
Completed NCT03165630 - Stroke Patients' Outpatient Rehabilitation Therapy (SPORT) N/A
Recruiting NCT05944666 - Substantiation and Standardization of the Multimodal Cognitive-motor Rehabilitation System for Afterstroke Patients N/A
Enrolling by invitation NCT05447754 - Comparison of the Effects of Robotic Rehabilitation Versus Traditional Balance Training on Balance and Fear of Falling in Stroke Patients N/A
Completed NCT03798340 - Vibratory Perturbation-based Pinch Task Training for Stroke Patients N/A
Completed NCT02603718 - An Applicative On-line EEG Tool for Enhancing Treatment Efficacy N/A
Completed NCT05391919 - Multimodal Correction of Post-stroke Motor and Cognitive Impairments N/A
Recruiting NCT05945212 - Effects of Local Vibrations Program of Dorsiflexor Muscles on Neuromotor Recovery in Subacute Stroke Patients. N/A
Completed NCT04753931 - Effects of Sensory Training Application in Addition to Bobath Training N/A
Recruiting NCT03866057 - Post Stroke Intensive Rehabilitation