Application of the Triple Stimulation Technique to Patients With CNS Disorders Including Stroke

Stroke Patients Clinical Trial

Official title:

Application of the Triple Stimulation Technique to Patients With CNS Disorders Including Stroke

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02354248
• Other study ID #: CHUB-TST01
• Status: Completed
• Phase: N/A
• First received: January 23, 2015
• Last updated: January 18, 2018
• Start date: June 11, 2014
• Est. completion date: September 13, 2016

Study information

• Verified date: January 2018
• Source: Brugmann University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

TST (Triple stimulation technique) helps to better quantify the proportion of motor units activated by transcranial magnetic stimulation. The abnormal amplitude registered by TST is proportional to the intensity of conduction disorders. The evaluation of these disorders is more precise with this technique than with the slowing of the central conduction time (CCT).

The investigators propose to use this technique in CNS pathologies where this disorder is significant and essential, like multiple sclerosis and stroke.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: September 13, 2016
• Est. primary completion date: September 13, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• stroke patients with hemiparesia

Exclusion Criteria:

• pace maker

• epilepsia

• metallic neurosurgical implants

Related Conditions & MeSH terms

• Stroke
• Stroke Patients

Intervention

Procedure:
• Triple stimulation technique
Evoked motor potentials obtained by magnetic transcranial stimulation are usually used, in standard practice, to evaluate the corticospinal tract. This procedure combines two techniques: the magnetic stimulation and the electroneuromyography. It is based on the double collision principle between the descending central stimulation (magnetic) and the ascending peripheric stimulation, hereby suppressing the issue of desynchronisation of evoked motor potentials. The Triple stimulation technique allows a better quantification of the proportion of motor units activated by the transcranial stimulation.

Locations

Country	Name	City	State
Belgium	CHU Brugmann	Brussels

Sponsors (1)

Lead Sponsor	Collaborator
Brugmann University Hospital

Country where clinical trial is conducted

Belgium, 

References & Publications (2)

Magistris MR, Rösler KM, Truffert A, Landis T, Hess CW. A clinical study of motor evoked potentials using a triple stimulation technique. Brain. 1999 Feb;122 ( Pt 2):265-79. — View Citation

Magistris MR, Rösler KM, Truffert A, Myers JP. Transcranial stimulation excites virtually all motor neurons supplying the target muscle. A demonstration and a method improving the study of motor evoked potentials. Brain. 1998 Mar;121 ( Pt 3):437-50. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Amplitude of the motor evoked potentials		during the TST (30 min)
Primary	Surface of the motor evoked potentials		during the TST (30 min)
Primary	Amplitude ratio of the TST		during the TST (30 min)
Primary	Surface ratio of the TST		during the TST (30 min)
Primary	TMS threshold		during TST (30 min)