Stress Clinical Trial - Effects of Butyrate on Affective Processes

Status Completed

Clinical Trial Summary

The effects of butyrate on psychobiological processes are examined in a sample of healthy volunteers.

Clinical Trial Description

The study is an interventional triple-blind, placebo-controlled, parallel group design with 2 arms (placebo, butyrate). Healthy male participants adhere to a low-fiber diet for the duration of the study (11 days). At the baseline study visit, measurements are taken in the lab, including biological samples and psychophysiological measurements. Participants then consume placebo or butyrate for 1 week and revisit the lab on day 11 for a second measurement of the outcomes of interest. Specifically, we investigate the effect of colonic butyrate administration on affective processing, including stress sensitivity and fear-related processes (e.g. extinction learning). Volunteers also respond to questionnaires in relation to mood and GI symptoms, and provide biological samples (saliva, blood, and faecal samples) for analysis of cortisol levels, circulating short chain fatty acids and serum BDNF, and faecal SCFA, respectively. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04722549
Study type	Interventional
Source	KU Leuven
Contact
Status	Completed
Phase	N/A
Start date	February 8, 2021
Completion date	December 11, 2022

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