Stress Clinical Trial - Effects of Dietary Fiber on Affective Processes

Status Completed

Clinical Trial Summary

The effects of dietary fiber on psychobiological processes are examined in a sample of healthy volunteers.

Clinical Trial Description

The study is an interventional triple-blind, placebo-controlled, parallel group design with 2 arms (placebo, dietary fiber). Healthy male participants adhere to their normal eating habits for the duration of the study (32 days). At the baseline study visit, measurements are taken in the lab, including biological samples and psychophysiological measurements. Participants then consume placebo or dietary fiber for 4 weeks and revisit the lab on day 32 for a second measurement of the outcomes of interest. Specifically, we investigate the effect of dietary fiber on affective processing, including stress sensitivity and fear-related processes (e.g. extinction learning). Volunteers also respond to questionnaires in relation to mood and GI symptoms, and provide biological samples (saliva, blood, faecal, and urine samples) for analysis of cortisol levels, circulating short chain fatty acids and serum BDNF, faecal SCFA and microbiota composition, and intestinal permeability, respectively. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04522258
Study type	Interventional
Source	KU Leuven
Contact
Status	Completed
Phase	N/A
Start date	May 2, 2019
Completion date	November 8, 2020

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