Stress Clinical Trial
Official title:
Effects of Different Driving Pressure on Lung Stress, Strain and Mechanical Power in Patients With Moderate to Severe ARDS
ARDS is the most common acute respiratory failure in the ICU and the mortality rate is still
as high as 40%. Mechanical ventilation(MV) is the major supportive treatment for ARDS, but
inappropriate ventilator setting could lead to patients suffering from Ventilator-Induced
Lung Injury(VILI).
VILI is an important factor in the aggravation of lung injury during MV. The main mechanism
of VILI is the unreasonable pressure change (stress) causing excessive local stretch of the
lung (strain), which eventually exceeds the capacity of the lung.
The protective strategies during MV (limited platform pressure, low tidal volume, suitable
PEEP) are important means of avoiding VILI during MV. The essences of these strategies are to
limit the stress and strain of the lung during MV. However, these lung protective ventilation
strategies only start from a single indicator and have certain limitations. Considering the
various shortcoming of the current strategies, Amato et al. combined two indicators and
proposed the concept of driving pressure(driving pressure=tidal volume/respiratory
compliance). Several studies also confirmed that limiting the driving pressure can
significantly improve patients' outcomes. But the concept of driving pressure and its safety
threshold have certain limitations.
Taking into the limitations of existing low tidal volume, limited platform pressure, and
restricted driving pressure strategies in lung protection ventilation, Gattinoni et al. first
integrated the all factors such as driving pressure, respiratory rate, airway resistance,
respiratory rate and PEEP together and the concept of mechanical power was formally
proposed.There is a good correlation between mechanical power and lung strain in a certain
PEEP range. Cressoni et al. demonstrated through animal experiments that excessive mechanical
power during MV caused significant VILI in animals; Guérin et al. also found that mechanical
power was closely related to patient outcome in patients with ARDS. Not only that, but
Gattinoni reanalyzed Güldner's experimental data and found that mechanical power is more
valuable in reflecting lung damage than driving pressure. Mechanical power is a good
indicator of response to patient VILI.
Therefore, the investigators hypothesized that only limiting the driving pressure during MV
of patients could not achieve ideal lung protective ventilation. Mechanical power may be a
better indicator of response VILI; and the safety threshold of driving pressure based on
retrospective analysis may not be suitable for patients with severe ARDS, and a lower driving
pressure can protect patients with severe ARDS. This study intends to use a single-center,
self-controlled study design to reflect lung injury through stress and strain and mechanical
work of the lungs, to verify the safety of different driving pressures for severe ARDS, and
to further find a safer driving margin for patients with severe ARDS
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