Stress Clinical Trial
Official title:
Comparison Between IV Propofol and Propofol/ Fentanyl Anesthesia on Patients Surgical Stress Response Using BIS
It is hypothesized that propofol, when used in general anesthesia (GA) influence patient's stress status and consequently affect stress response parameters. Hence, the objective of the presented research is to assess whether the propofol has anti-stress effect or not in patients undergoing surgeries that require GA and classified as The American Society of Anesthesiologists physical status 1 (ASA PS1)
- Forty patients will be divided into two groups of patients (n=20 each), where in the
first group anesthesia induction will be with propofol as a single agent, while
patients in the second group will be anesthetized by propofol/fentanyl and the depth of
anesthesia will be determined by BIS score and will be kept at 40-60.
- In both groups, blood will be withdrawn to assess the possible effect of these
medications on stress by measuring the following parameters:
I- Hemodynamic indicators II- Catecholamines . III- Fasting blood glucose IV- Insulin level
V- Cortisol VI- Vasopressin
VII- Cytokines:
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