Stress Clinical Trial
Official title:
Genetic Biomarkers of Executive Stress
The purpose of this study is to examine whether stress predicts telomere length in individuals who hold executive-level positions. Telomeres are the caps at the end of each strand of DNA that may affect how cells age. Subjects will complete an online survey/interview and provide one blood sample or saliva samples. The goal is to understand whether stress predicts genetic markers of longevity.
The primary aim of this study is to evaluate the relationship between overall levels of
stress and telomere length. It is hypothesized that the high stress group (based on the
Perceived Stress Scale)compared to low stress group will have shorter telomere length. A
secondary aim is to evaluate whether different types of stress have differing degrees of
association with telomere length. An exploratory aim is to assess for gender differences in
the association between stress and telomere length. The investigators are collecting a number
of other measures, including demographics, work sector, perceived social support, and medical
history, in order to adjust for potential confounders in the analysis.
This study is an extension of earlier work Dr. Rasgon has done with Dr. Elizabeth Blackburn
at UCSF on the relationship between telomere length and mood outcomes. The investigators hope
this study will add to the growing body of literature on stress and genetic markers of
longevity, specifically how stress level and type is associated with telomere length. The
increased understanding gained through this study may provide leads for predicting
age-related diseases and early mortality in adults, thus benefiting others in the future.
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