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Stress Disorders, Traumatic clinical trials

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NCT ID: NCT01686438 Completed - Clinical trials for Sleep Initiation and Maintenance Disorders

Telemedicine Management of Chronic Insomnia

VIP
Start date: April 1, 2013
Phase: N/A
Study type: Interventional

Insomnia is commonly present in Veterans with post-traumatic stress disorder (PTSD). Treatment of insomnia with a specialized type of psychotherapy has been shown to be more effective than treatment with medications. Unfortunately, few psychologists are trained to provide this treatment, limiting Veterans' access to care, especially those Veterans in remote and rural areas. This project will evaluate the ability to deliver this psychotherapy to groups of Veterans by video teleconferencing. Groups of Veterans with PTSD and chronic insomnia will receive the psychotherapy treatment either by meeting in-person with the psychologist or by the psychologist delivering the treatment by video teleconferencing. Finding that video teleconferencing is a cost effective way to deliver this treatment could add an important new component to the care of Veterans with PTSD that provides an alternative to medications.

NCT ID: NCT01684085 Not yet recruiting - Clinical trials for Post Traumatic Stress Disorder

Explanation About Sleep in Post Trauma Patients

Start date: October 2012
Phase: N/A
Study type: Interventional

This study is designed to test the effect of an explanation about the first sleep following trauma exposure, on the development of Post Traumatic Stress Disorder (PTSD) in the months following the traumatic event.

NCT ID: NCT01681849 Completed - PTSD Clinical Trials

Neural Circuits in Women With Abuse and Posttraumatic Stress Disorder

Start date: July 2009
Phase: Phase 4
Study type: Interventional

The purpose of this study was to assess the effects of the medication paroxetine on symptoms of posttraumatic stress disorder (PTSD) and the brain in women with a history of PTSD related to childhood abuse. The hypothesis is that paroxetine will result in an improvement in PTSD symptoms accompanied by changes in brain functional response to reminders of childhood trauma.

NCT ID: NCT01681628 Completed - Clinical trials for Post-traumatic Stress Disorder

Community Self-help Using Thought Field Therapy in a Traumatised Population in Uganda: a Randomised Trial

Start date: June 2012
Phase: N/A
Study type: Interventional

Thought Field Therapy (TFT) is a simple technique that involves tapping on points of the body corresponding to the meridians used in acupuncture. By using specific sequences, TFT can be used to treat a variety of psychological problems. Patients can be taught to treat themselves, and lay people can be trained to treat others in their community, as has been shown for narrative exposure therapy. Thought Field Therapy has been used to treat whole communities who have suffered psychological trauma following natural disasters and violent conflicts. In these circumstances, TFT can be used as a stand-alone therapy, or as an adjunct to other psychological therapies, by removing the pain of re-living the traumatic events. Studies in Rwanda have shown that individuals within a community can be treated with brief TFT sessions. Both short-term and longer-term improvements in scores of Post-Traumatic Stress Disorder (PTSD) measurement scales have been demonstrated. The Kasese District has suffered from factional conflicts and the consequences of the ongoing struggles in neighbouring countries for many years. Although the government has controlled the situation and secured the borders, many are still haunted by the psychological consequences. The purpose of the study is to validate the model of addressing widespread psychological trauma following conflict by training community leaders to help others in their community using TFT. Thirty-six community leaders will be given a two-day training in algorithm level trauma-relief TFT. They will then treat 128 volunteers for their traumas, using TFT, who will be assessed before and after treatment by the post-traumatic stress disorder check-list questionnaire for civilians (PCL-C). As a control, a further 128 volunteers will join a wait-list group, who will be assessed at the same time, but treated later. PCL-C scores before and after treatment will be compared with the wait-list group scores before and after waiting, but before their treatment. A follow-up assessment of the participants will be undertaken 1 to 2 years later.

NCT ID: NCT01672684 Completed - Depression Clinical Trials

Phase I: At-Home Support for Rural Women Using Group Video Calling

Start date: October 2012
Phase: Phase 1
Study type: Interventional

This randomized phase I trial studies at-home group video calling sessions in quality of life in rural patients with breast cancer. At-home group video calling support sessions may improve the well-being and quality of life of women who have breast cancer

NCT ID: NCT01667822 Completed - Anxiety Disorders Clinical Trials

Cognitive Behavioral Therapy, Guided Self Help Versus Individual Therapy

Start date: August 2012
Phase: Phase 3
Study type: Interventional

Background: Studies show that about 1 out of 3 patients in Primary Care suffer primarily from mental health disorders, such as anxiety disorders and depression. Cognitive behavior therapy (CBT) has been shown to be an effective treatment of these disorders. Despite the strong evidence for CBT there is a lack of evidence-based psychological treatment in primary care. For various reasons, the progress of research has not affected clinical practice. For successful implementation of CBT in primary care cost-effective therapies, access to therapists with proper training and supervision, evidence-based manuals and management that support the implementation is needed. Aim: The aim of this trial is to evaluate a stepped care model with CBT in primary care. All patients are first treated with self-help CBT (N = 400). Patients that do not improve after treatment (9 weeks) are randomized to individual CBT or continued self-help treatment. Based on published studies 2/3 is expected to be improved after self-help and therefore do not undergo randomization. 1/3 (n = 133) who didn´t respond to treatment is randomized to individual CBT (N = 67) or continued self-help treatment (N = 67).

NCT ID: NCT01667809 Completed - Anxiety Disorders Clinical Trials

CBT vs RTW Intervention for Patients With Common Subclinical Mental Illness in Primary Care

Start date: August 2012
Phase: Phase 3
Study type: Interventional

Background: Common mental illness, such as anxiety disorders and depression, is the main cause for sick leave in Sweden. Cognitive behavior therapy (CBT) has been shown to be effective in alleviating target symptoms of these disorders, but its effect on sick leave rates has not been sufficiently addressed. The investigators have developed an intervention called return to work (RTW), which is based in cognitive behavioral theory, that has a primary aim of helping sick-listed patients with common mental illness return to work. This new treatment has not been evaluated in a randomized controlled trial. Aims: The aim of this study is to investigate the effect of CBT and RTW for subclinical common mental illness in a randomized controlled trial conducted in primary care. Participants will be randomized to diagnosis specific CBT (n=50), RTW (n=50. Main outcomes are days of sick leave and clinician severity rating of psychiatric symptoms. This study could contribute to new knowledge regarding how to best treat patients on sick leave with mild common mental illness.

NCT ID: NCT01664260 Withdrawn - Clinical trials for Posttraumatic Stress Disorder

Efficacy Mechanism of N-acetylcysteine in Patients With Posttraumatic Stress Disorder

Start date: November 1, 2012
Phase: Phase 2
Study type: Interventional

It has been suggested that N-acetylcysteine exerts neuroprotective effects by regulating neurotransmitters and cell signaling pathways. We hypothesize that oral N-acetylcysteine augmentation will help reduce symptoms in patients with posttraumatic stress disorder as well as improve cognitive functions. We also expect that the N-acetylcysteine augmentation will induce change in structural, functional, and neurochemical aspects of the brain. In this study, we plan to conduct a randomized, double-blind, placebo-controlled augmentation study with N-acetylcysteine in addition to escitalopram. We will assess the efficacy and safety of the N-acetylcysteine augmentation.

NCT ID: NCT01661452 Completed - Clinical trials for Development of PTSD After Natural Disaster

Development of Post Traumatic Stress Disorder After Natural Disaster

Start date: June 2011
Phase: N/A
Study type: Observational

A survey (patient self-report) of patients presenting to UAB emergency room, outpatient trauma clinics and substance abuse center for symptoms of post-traumatic stress disorder and maladaptive coping responses after the widespread tornado disaster that occurred in Alabama in April 2011.

NCT ID: NCT01658748 Withdrawn - Clinical trials for Post Traumatic Stress Disorder

A Pilot Study of Deep Brain Stimulation of the Amygdala for Treatment-Refractory Combat Post-Traumatic Stress Disorder

ADIP
Start date: January 2013
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether deep brain stimulation of the basolateral nucleus (BLn) of the amygdala, on both sides of the brain, can safely reduce symptoms of post-traumatic stress disorder (PTSD) in combat veterans whose condition has not improved despite extensive treatment with currently available medication and psychotherapy interventions.