Train Your Brain: Neurofeedback Intervention for PTSD

Status Terminated

Clinical Trial Summary

The investigator's aim is to evaluate the efficacy of two types of neurofeedback treatments for PTSD symptoms reduction. Half of the participants will receive the current standard for PTSD neurofeedback care undergoing alpha/theta neurofeedback regulation. The other half will receive the newly developed limbic modulation index neurofeedback.

Clinical Trial Description

Traumatic stress is commonly resistant to existing therapeutics, possibly due to high treatment dropout rates along with a failure to target the relevant underlying neural mechanisms. Neuromodulation of deep limbic areas such as the amygdala may play a critical role in the effective recovery from traumatic stress. Human studies have shown the importance of such modulation during the encoding of traumatic stimuli, showing greater amygdala activation for subsequently remembered traumatic stimuli. In addition, a prospective study among previously healthy soldiers showed that hyper-activation of the amygdala prior to military traumatic exposure corresponded with more severe post-traumatic symptoms following exposure. Together these finding points to the amygdala as a plausible neuromodulation target for preventive or early interventions of post-traumatic disturbances. Local neuromodulation of the amygdala could improve treatment specificity and the overall intervention outcome. The main goal of the suggested research is to further develop and implement a non-invasive, portable and cost-effective brain-imaging tool that will provide individual on-line guidance for amygdala modulation. This closed-loop brain training will enhance individual resilience to and coping with potentially traumatic stress as well as alleviate consequential psychopathologies. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03858933
Study type	Interventional
Source	University of Southern California
Contact
Status	Terminated
Phase	N/A
Start date	April 19, 2018
Completion date	December 31, 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05620381` - Health and Sleep Assessment After the Strasbourg Attacks of December 11, 2018
Completed	`NCT02856412` - Improving Mind/Body Health and Functioning With Integrative Exercise	N/A
Recruiting	`NCT05400200` - PTSD and Self-regulation: Coping, Emotional Regulation and Cognitive Control and Their Relationships to Symptom Management	N/A
Not yet recruiting	`NCT06088303` - Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication	N/A
Not yet recruiting	`NCT03652922` - Propranolol Reactivation Mismatch (PRM) Treatment for PTSD	Phase 4
Completed	`NCT02875912` - Prospective Evaluation of Family Care Rituals in the ICU	N/A
Completed	`NCT01589575` - Anxiety and Depression in Relatives of Critically Ill Patients: Spouses Versus Other Close Relatives	N/A
Completed	`NCT00990106` - Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD)	N/A
Completed	`NCT01291368` - Sedation Influence on Delirium and Post-traumatic Stress-disorder as a Result of Hospitalization in Intensive Care	N/A
Active, not recruiting	`NCT00657787` - Development of a Post-Traumatic Stress Disorder (PTSD) Population Registry for Veterans
Completed	`NCT00835627` - Treatment Trial for Psychogenic Nonepileptic Seizures	Phase 4
Completed	`NCT01365247` - Concurrent Treatment for Substance Dependent Individuals With Post-Traumatic Stress Disorder (PTSD)	N/A
Completed	`NCT00880152` - Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder: A Pilot Study	N/A
Completed	`NCT00419029` - Motivational Interviewing to Engage Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans in Mental Health Treatment	N/A
Completed	`NCT00514956` - Effect of Emotional Freedom Technique and Diaphragmatic Breathing on Post Traumatic Stress Disorder (PTSD)	Phase 1
Completed	`NCT00333710` - Evaluating a Telehealth Treatment for Veterans With Hepatitis C and PTSD	N/A
Completed	`NCT01120847` - Post Traumatic Stress Disorder (PTSD), Sleep Disordered Breathing And Genetics: Effects On Cognition
Completed	`NCT00069225` - Brain Structure and Function Before and After Treatment for Post-Traumatic Stress Disorder	N/A
Completed	`NCT00055354` - Acupuncture for the Treatment of Post-Traumatic Stress Disorder (PTSD)	N/A
Completed	`NCT00186212` - Alternative Support for Rural and Isolated Women in an HMO	Phase 3