Stress Disorders, Post-Traumatic Clinical Trial
Official title:
Stress and Emotional Memory : Functional Neuroanatomy of Post-traumatic Stress Disorder in Adolescents
A broad group of disorders is associated with severe stress existence in children or
adolescents. The most characteristic result, and one of the most serious being the state of
post-traumatic stress disorder (PTSD), whose main source consists of physical or sexual
violence, and to a lesser extent, accidents public road or natural disaster, whose child was
the subject or witness. PTSD is associated with a deleterious effect on cognition and
including the mnemonic operation. The painful reminder of the traumatic event is one of the
most disabling symptoms. However, there are many other memory disorders that experimental
studies gradually update. They maintain a close link with emotional regulation that
disturbed you know if PTSD. However the majority of studies on emotion and cognition and
their relationship with brain activity took adult subject. Work in adolescents are few on
the morphological study, on rare neurobehavioral and reduced to two studies of functional
neuroimaging. Contrary to what is observed in adults, morphological studies report
consistently, no reduction in hippocampal volume. There is no study in the idle state. Two
studies in functional MRI, the first highlighted in PTSD patients inhibition of the activity
of the anterior cingulate cortex (ACC) to stimuli such as to evoke the trauma, a second
reported increased activity in the prefrontal cortex Median (mPFC) in a inhibition. The
objective task of our study is to evaluate the impact of psychological trauma on brain
structures involved in the emotional component of the memory (amygdala, hippocampus,
prefrontal cortex in particular). For this, the investigators will take in 33 adolescents,
including patients with posttraumatic symptomatology and matched controls free of trauma
age, several neuroimaging exams, anatomical and functional. The functional review will
include some rest and another in activation during episodic memory task designed to assess
the influence of self-perception on memory impairment observed in patients. The
investigators will check, for each group of patients and controls, the involvement of
cortical structures in relation to the regulation of emotional memory (CCA, amygdala and
hippocampus). The anatomy of the hippocampus benefit specific imaging methods developed in
the unit INSERM U923. Endocrine correlates of stress tests will be studied by a
fully-traumatic by salivary cortisol sampling.
This research will clarify the mechanisms involved in emotional and memory impairments
secondary to psychological trauma, their relationship with self (judgment and self-esteem)
and studying their morphological substrates. A longer-term goal is to offer help in the
diagnosis and monitoring of young patients with posttraumatic symptomatology.
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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