Quetiapine Augmentation for Treatment-resistant PTSD

Status Completed

Clinical Trial Summary

The purpose of this study is to compare the response of veterans with PTSD without an optimal response to paroxetine to quetiapine augmentation versus placebo.

Clinical Trial Description

This is a two-site study designed to evaluate the efficacy and safety of quetiapine augmentation of paroxetine treatment in veterans with PTSD who have failed to respond to paroxetine treatment.

In Phase I, eligible patients will take open-label paroxetine (up to 60 mg daily) for 8 weeks. Patients who are refractory (less than 30% reduction in CAPS scores or a minimum CAPS score of 50 at week 8) and have PTSD symptoms of at least moderate severity on CGI-S will be eligible for the second phase. In Phase II, patients will continue taking open-label paroxetine and will be randomized to the addition of quetiapine (up to 800 mg daily) or placebo for 8 weeks in a double-blind fashion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00292370
Study type	Interventional
Source	VA Office of Research and Development
Contact
Status	Completed
Phase	Phase 4
Start date	January 2006
Completion date	May 2009

View Details

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