Streptococcal Infections Clinical Trial
Official title:
Efficacy of Brazilian Green Propolis Varnish Against Streptococcus Mutans in Saliva: a Phase II Study.
This study aims to evaluate the effectiveness of a varnish containing 15% of green propolis on Streptococcus mutans in saliva and biofilm. Will be invited to join the study: children 8-10 years old, free of caries, without orthodontic appliances and without having undergone antibiotic therapy until three weeks before the start of the study. Saliva will be collected before, immediately after, 24 hours and 30 days after application of the varnish. The collection of biofilm will be performed before, after, 24 hours and 30 days after application of the varnish. Data will be collected and compared between periods.
Status | Completed |
Enrollment | 11 |
Est. completion date | July 2015 |
Est. primary completion date | January 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 8 Years to 10 Years |
Eligibility |
Inclusion Criteria: - children 8-10 years old - good general health condition - not making use of mouthwashes or medications (especially antibiotics), until three weeks prior to the beginning of the experiment. Exclusion Criteria: - Patients in medical treatment or who used drugs (especially antibiotics), in the three previous weeks and patients with active caries lesions. |
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Federal University of Minas Gerais | Conselho Nacional de Desenvolvimento Científico e Tecnológico, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Streptococcus mutans in saliva and in tooth biofilm | 30 days | Yes | |
Secondary | Caries incidence reduction | Up to 24 months | Yes |
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