Streptococcal Infections Clinical Trial
Official title:
Comparative Trial of Oral Penicillin Versus Cefuroxim for Treatment of Perianal Dermatitis - an Open, Randomized, Controlled Trial
The goal of the study is to investigate, which of two antibiotic treatments - oral penicillin for 10 days or oral cefuroxim for 7 days - is more successful for patients (1-16 years of age) with perianal dermatitis caused by group A beta-hemolytic streptococci.
The goal of the study is to investigate, which of two antibiotic treatments - oral
penicillin for 10 days or oral cefuroxim for 7 days - is more successful for patients (1-16
years of age) with perianal dermatitis caused by group A beta-hemolytic streptococci
(GABHS). Diagnosis is based on positive perianal culture for GABHS. Informed consent will be
obtained.
The study will be performed in the region of Basel, Switzerland, in private practices of
pediatricians, general practitioners, and selected pediatric dermatologists as well as in
the out-patient departments of the University Children's Hospital Basel and the department
for dermatology of the University of Basel.
Patients (or their parents) will fill in a daily diary on signs and symptoms of disease;
furthermore, clinical investigations (inspection of the site of infection) will be performed
on enrollment (Day 1), Day 3, and at the end of treatment (Day 10).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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